CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1633770
A collision tumor composed of colon adenocarcinoma and large cell neuroendocrine carcinoma with gingival metastasis: A case report
Provisionally accepted
- 1North Sichuan Medical College, Nanchong, China
- 2Gastrointestinal Surgery, Suining Central Hospital, Suining, China
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Collision tumors represent a relatively uncommon form of tumor manifestation, characterized by the independent coexistence of multiple distinct types of tumors.Large cell neuroendocrine carcinoma of the colorectum is a rare entity, with limited reports describing collision tumors involving adenocarcinoma and large cell neuroendocrine carcinoma. Distant metastases of colorectal cancer typically occur in sites such as bone, liver, and lungs; however, metastasis to the gingiva is rarely encountered. This paper reports a case of a collision tumor comprising colonic adenocarcinoma and large cell neuroendocrine carcinoma, with accompanying gingival metastasis.
Keywords: Colon adenocarcinoma, Large cell neuroendocrine carcinoma, Collision Tumor, Gingival metastasis, Neuroendocrine transformation
Received: 23 May 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Zhang, Chen, Zhang, Lan and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yunsheng Lan, Gastrointestinal Surgery, Suining Central Hospital, Suining, China
Yingdong Jia, Gastrointestinal Surgery, Suining Central Hospital, Suining, China
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