Your new experience awaits. Try the new design now and help us make it even better

GENERAL COMMENTARY article

Front. Oncol., 18 July 2025

Sec. Thoracic Oncology

Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1633958

Commentary: Defining long-term survivors in metastatic lung cancer: insights from a Delphi study in Spain

Javier-David Benitez-Fuentes*Javier-David Benitez-Fuentes1*Pablo Oliva MarinPablo Oliva Marin2Beatriz Grau MireteBeatriz Grau Mirete1Samer Alhallak AlhallakSamer Alhallak Alhallak3Paula Rodríguez PayPaula Rodríguez Payá1Asia Ferrndez AriasAsia Ferrández Arias1
  • 1Medical Oncology Department, Hospital General Universitario de Elche, Elche, Spain
  • 2Primary Care Department, Centro de Salud Integrado de Santa Pola, Departamento de Salud de Elche-Hospital General, Santa Pola, Spain
  • 3Primary Care Department, Centro de Salud de Torrellano, Departamento de Salud de Elche-Hospital General, Torrellano, Spain

A Commentary on:
Defining long-term survivors in metastatic lung cancer: insights from a Delphi study in Spain

by Carcereny E, Domine M, Ortega Granados AL (2025). Front. Oncol. 15:1546019. doi: 10.3389/fonc.2025.1546019

Introduction

Carcereny et al. present a valuable Delphi consensus that aims to standardize what it means to be a “long-term survivor” (LTS) in metastatic lung cancer (mLC). Such a definition is especially relevant now that immunotherapy and targeted treatments have reshaped the prognosis in advanced disease (1). Their threshold of ≥3 years of overall survival (or ≥2 years of progression-free survival) offers a reference point for both clinical practice and future research (1). This nationwide expert effort reflects the growing body of literature demonstrating that metastatic lung cancer is no longer invariably a short-term illness (2).

The authors appropriately highlight the oncological challenges of detecting second neoplasms, immune-mediated toxicities and the broader psychosocial and rehabilitative needs these long-term survivors face (1). Many individuals living with advanced cancer experience fatigue, fear of recurrence, financial toxicity, and difficulties reintegrating into work or community life (3). Based on experiences in other tumor settings, such as breast or colorectal cancer, where extended survival has been observed for decades, collaboration between oncologists and primary care physicians (PCPs) can strengthen survivorship care (4).

Carcereny et al. report that 70.7% of their Delphi panel agreed the follow-up of long-term survivors of lung cancer should not be carried out in primary care, while there was no clear consensus about follow-up being conducted exclusively in specialized units (agreement 53.7%) (1). In this commentary, we differ from their position regarding primary care follow-up. We suggest that their conclusion likely reflects a cautious assessment of the current limitations in primary care infrastructure. However, we advocate transitioning toward a primary care-led or shared-care follow-up model after an initial oncology-led period. Greater investment and improved resources could enable primary care providers to better address the needs of mLC survivors, ultimately enhancing the resilience of the health system.

Why the follow-up of long-term survivors of lung cancer should be carried out in primary care or in shared-care models

There is evidence that primary care–led or co-led models may improve long-term outcomes, quality of life, and possibly cost-efficiency. PCPs and other primary care providers such as nurses and social workers hold deep knowledge of their patients’ comorbidities, social contexts, and lifestyles, allowing them to approach survivorship holistically. This continuity of care could be critical in ensuring that screening for secondary malignancies, and management of chronic conditions are integrated into the patient’s care plan (58).

Patients with a history of advanced malignancies may develop a variety of post-treatment effects, some of which are subtle, cumulative, and often mistaken for normal aging or other comorbidities. PCPs, thanks to frequent and less specialized visits, are well positioned to detect new or evolving symptoms—ranging from respiratory complaints to changes in mental health—offering pathways back into oncology if alarm signs arise (8). Regular interactions with primary care may also foster a preventive approach as PCPs and their allied primary care teams are accustomed to recommending lifestyle changes and screening for other diseases, reinforcing beneficial behaviors that reduce the risk of recurrences and secondary tumors (8, 9).

When managed carefully, primary care–led or shared-care follow-up can be cost-effective, reducing avoidable specialist appointments and shortening diagnostic delays (10). Ongoing primary care involvement in cancer survivor follow-up could enhance satisfaction and timeliness of care, partly because PCPs and primary care teams address a broad range of issues in a single visit (8). Evidence from integrated care models demonstrates that transitioning cancer survivors from specialty to primary care maintains cancer-specific outcomes while simultaneously enhancing management of general health issues, providing better supportive care, and reducing overall healthcare costs compared to specialist-led models (8).

Importantly, strengthening primary care may also improve the performance, efficiency, and resilience of the entire health system (6, 11). A comparative analysis underscored how countries with strong primary care foundations consistently outperform others in terms of better overall health outcomes, lower costs, and greater equity in healthcare provision (12). Similarly, a comprehensive assessment argued that health systems built on a robust primary care infrastructure exhibit increased resilience, responding more effectively to population needs both during routine care and health crises such as the COVID-19 pandemic (13).

Discussion

Implementing primary care–led follow-up requires addressing several concerns. Studies have noted potential drawbacks, for example, the possibility of delayed recognition of cancer recurrence if surveillance is less intensive, limited oncology-specific expertise among some PCPs, and many survivors’ preferences to continue seeing oncology specialists for follow-up (1418). Indeed, certain high-risk survivors, such as those with very aggressive tumors or complex treatment-related complications, may need ongoing specialist oversight, given the specialized knowledge required to manage their surveillance and late effects (17). Such concerns were perhaps reflected in the Delphi panel led by Carcereny et al., which concluded that follow-up of long-term survivors should not occur in primary care, possibly due to perceived limitations in current primary care capabilities.

Nevertheless, we disagree with this conclusion, emphasizing instead that primary care’s role could—and should—be expanded through increased investment and resources. The optimal approach may be an initial oncology-led follow-up tailored according to treatment complexity and emerging evidence, transitioning to primary care or shared-care follow-up for routine survivorship visits if the patient remains stable. Such a model requires clear guidelines, support and training for PCPs and their multidisciplinary primary care teams and streamlined pathways for prompt re-access to oncology services when and if necessary. Making primary care a fully capable partner requires an investment in infrastructure and additional workforce training. Adequate resources, such as enhanced electronic health records, improved training in recognizing late immunotherapy side effects, and robust communication channels with oncology, will ensure that responsibilities are not shifted without support.

A summary of the key benefits supporting primary care-led follow-up is provided in Table 1.

Table 1
www.frontiersin.org

Table 1. Advantages of primary care–led follow-up for long-term survivors of metastatic lung cancer, key reasons and their justifications.

The Delphi study by Carcereny et al. makes a valuable contribution by defining “long-term survivor” in metastatic lung cancer and underscoring the complexities of caring for these survivors. Their consensus strongly validates the importance of specialized monitoring for toxicity and disease progression (1). Yet an equally vital role for primary care teams, including PCPs, nurses, social workers, and other primary care professionals is now in sharper focus. By integrating the expertise of oncologists during the initial phases following treatment—tailored to clinical complexity and evolving evidence—with the holistic, patient-centered care provided subsequently by primary care, health services can comprehensively address patients’ comorbidities, psychosocial needs, and preventive health strategies, provided patient stability is maintained. Although such a model requires infrastructure, workforce expansion, and ongoing collaboration, the long-term dividends, improved cost efficiency, better patient access, enhanced early detection of complications, and a stronger health system overall, are likely substantial.

Author contributions

JF: Supervision, Conceptualization, Writing – review & editing, Resources, Visualization, Validation, Writing – original draft, Project administration, Funding acquisition. PM: Validation, Supervision, Writing – original draft, Conceptualization, Writing – review & editing. BM: Conceptualization, Writing – original draft, Writing – review & editing. SA: Writing – review & editing, Writing – original draft, Conceptualization. PP: Writing – original draft, Conceptualization, Writing – review & editing. AA: Writing – original draft, Conceptualization, Project administration, Validation, Writing – review & editing, Supervision.

Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Generative AI statement

The author(s) declare that no Generative AI was used in the creation of this manuscript.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

1. Carcereny E, Domine M, and Ortega Granados AL. Defining long-term survivors in metastatic lung cancer: insights from a Delphi study in Spain. Front Oncol. (2025) 15. doi: 10.3389/fonc.2025.1546019, PMID: 40255426

PubMed Abstract | Crossref Full Text | Google Scholar

2. Remon J, Hendriks LEL, and Besse B. Paving the way for long-term survival in non-small-cell lung cancer. J Clin Oncol. (2021) 39:2321–3. doi: 10.1200/JCO.21.00760, PMID: 34101497

PubMed Abstract | Crossref Full Text | Google Scholar

3. Pangestu S and Rencz F. Comprehensive score for financial toxicity and health-related quality of life in patients with cancer and survivors: A systematic review and meta-analysis. Value Health. (2023) 26:300–16. doi: 10.1016/j.jval.2022.07.017, PMID: 36064514

PubMed Abstract | Crossref Full Text | Google Scholar

4. Virgo KS, Lerro CC, Klabunde CN, Earle C, and Ganz PA. Barriers to breast and colorectal cancer survivorship care: perceptions of primary care physicians and medical oncologists in the United States. J Clin Oncol. (2013) 31:2322–36. doi: 10.1200/JCO.2012.45.6954, PMID: 23690429

PubMed Abstract | Crossref Full Text | Google Scholar

5. Vos JAM, Wieldraaijer T, van Weert HCPM, and van Asselt KM. Survivorship care for cancer patients in primary versus secondary care: a systematic review. J Cancer Surviv. (2021) 15:66–76. doi: 10.1007/s11764-020-00911-w, PMID: 32815087

PubMed Abstract | Crossref Full Text | Google Scholar

6. Starfield B, Shi L, and Macinko J. Contribution of primary care to health systems and health. Milbank Q. (2005) 83:457–502. doi: 10.1111/j.1468-0009.2005.00409.x, PMID: 16202000

PubMed Abstract | Crossref Full Text | Google Scholar

7. Rubin G, Berendsen A, Crawford SM, Dommett R, Earle C, Emery J, et al. The expanding role of primary care in cancer control. Lancet Oncol. (2015) 16:1231–72. doi: 10.1016/S1470-2045(15)00205-3, PMID: 26431866

PubMed Abstract | Crossref Full Text | Google Scholar

8. Maddula M, Brown LJ, Gao B, Pires da Silva I, and Nagrial A. EP11.03–07 Long-term outcomes and toxicity in patients with metastatic non-small cell lung cancer treated with immunotherapy containing regimens. J Thorac Oncol. (2023) 18:S622. doi: 10.1016/j.jtho.2023.09.1179

Crossref Full Text | Google Scholar

9. Emmons KM and Colditz GA. Realizing the potential of cancer prevention—the role of implementation science. N Engl J Med. (2017) 376:986–90. doi: 10.1056/NEJMsb1609101, PMID: 28273020

PubMed Abstract | Crossref Full Text | Google Scholar

10. Emery JD, Shaw K, Williams B, Mazza D, Fallon-Ferguson J, Varlow M, et al. The role of primary care in early detection and follow-up of cancer. Nat Rev Clin Oncol. (2014) 11:38–48. doi: 10.1038/nrclinonc.2013.212, PMID: 24247164

PubMed Abstract | Crossref Full Text | Google Scholar

11. World Health Organization. Primary health care. Available online at: https://www.who.int/news-room/fact-sheets/detail/primary-health-care (Accessed April 27, 2025).

Google Scholar

12. Doty MM, Tikkanen R, Shah A, and Schneider EC. Mirror, Mirror 2021: Reflecting Poorly. Health Care in the U.S. Compared to Other High-Income Countries. Commonwealth Fund. (2021). doi: 10.26099/01dv-h208

Crossref Full Text | Google Scholar

13. Lal A and Schwalbe N. Primary health care: a cornerstone of pandemic prevention, preparedness, response, and recovery. Lancet. (2023) 401:1847. doi: 10.1016/S0140-6736(23)00963-7, PMID: 37216957

PubMed Abstract | Crossref Full Text | Google Scholar

14. Walter FM, Usher-Smith JA, Yadlapalli S, and Watson E. Caring for people living with, and beyond, cancer: an online survey of GPs in England. Br J Gen Pract. (2015) 65:e761–8. doi: 10.3399/bjgp15X687409, PMID: 26500324

PubMed Abstract | Crossref Full Text | Google Scholar

15. Potosky AL, Han PK, Rowland J, Klabunde CN, Smith T, Aziz N, et al. Differences between primary care physicians’ and oncologists’ knowledge, attitudes and practices regarding the care of cancer survivors. J Gen Intern Med. (2011) 26:1403–10. doi: 10.1007/s11606-011-1808-4, PMID: 21785923

PubMed Abstract | Crossref Full Text | Google Scholar

16. Jefford M, Howell D, Li Q, Lisy K, Maher J, Alfano CM, et al. Improved models of care for cancer survivors. Lancet. (2022) 399:1551–60. doi: 10.1016/S0140-6736(22)00306-3, PMID: 35430022

PubMed Abstract | Crossref Full Text | Google Scholar

17. Jacobs LA and Shulman LN. Follow-up care of cancer survivors: challenges and solutions. Lancet Oncol. (2017) 18:e19–29. doi: 10.1016/S1470-2045(16)30386-2, PMID: 28049574

PubMed Abstract | Crossref Full Text | Google Scholar

18. Peppercorn J. Transition to what? JCO Oncol Pract. (2025) 21:731–3. doi: 10.1200/OP-25-00417, PMID: 40505242

PubMed Abstract | Crossref Full Text | Google Scholar

Keywords: metastatic lung cancer, survivorship, primary care, health system, immunotherapy, multidisciplinary care

Citation: Benitez-Fuentes J-D, Marin PO, Mirete BG, Alhallak SA, Payá PR and Arias AF (2025) Commentary: Defining long-term survivors in metastatic lung cancer: insights from a Delphi study in Spain. Front. Oncol. 15:1633958. doi: 10.3389/fonc.2025.1633958

Received: 23 May 2025; Accepted: 01 July 2025;
Published: 18 July 2025.

Edited by:

Andrea De Giglio, University of Bologna, Italy

Reviewed by:

Morten Quist, University of Copenhagen, Denmark

Copyright © 2025 Benitez-Fuentes, Marin, Mirete, Alhallak, Payá and Arias. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Javier-David Benitez-Fuentes, amF2aWVyZGF2aWRiZW5pdGV6ZnVlbnRlc0BnbWFpbC5jb20=

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.