MINI REVIEW article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1634835
This article is part of the Research TopicReviews in Thoracic OncologyView all 3 articles
Lung Cancer Associated with Cystic Airspaces: Current Status and Challenges
Provisionally accepted
- Shenyang Tenth People's Hospital, Shenyang, China
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Lung cancer associated with cystic airspaces (LCCA) refers to primary lung cancers presenting with cystic airspaces accompanied by solid components, representing a relatively uncommon imaging and pathological phenotype. Although high-resolution imaging techniques, such as computerized tomography, are the primary diagnostic tools, early diagnosis remains challenging due to the similarity of its symptoms to other pulmonary diseases. Treatment options include surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy. However, due to the unique nature of LCCA, treatment requires a highly individualized approach. The main challenges currently faced include improving diagnostic accuracy, determining the optimal treatment strategies, and advancing the understanding of its underlying biological characteristics. Future research will focus on optimizing diagnostic techniques, developing targeted therapies for specific molecular markers, exploring the application of immunotherapies, and promoting multidisciplinary collaboration. With continuous advancements in technology and personalized treatment strategies, significant improvements in the diagnosis and treatment of LCCA are anticipated. This review summarizes the epidemiology, imaging features, pathological characteristics, pathogenesis, treatment strategies, and challenges of LCCA, and offers perspectives on future research directions.
Keywords: Lung cancer associated with cystic airspaces (LCCA), Imaging phenotype, diagnosis, Pathology, Challenges
Received: 25 May 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Wang, Feng, Song, Cao, Zhang, Yang and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yi Ren, Shenyang Tenth People's Hospital, Shenyang, China
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