REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1635209
YBX1: An RNA/DNA-binding protein that affects disease progression
Provisionally accepted
- Central South University, Changsha, China
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YBX1 is a member of the Y-box transcription factor family and is a multifunctional RNA/DNAbinding protein characterized by a highly conserved cold shock domain (CSD). YBX1 is localized in both the cytoplasm and nucleus, where it participates in various biological processes such as transcription, translation, and DNA damage repair. YBX1 is upregulated in numerous malignant tumors and is closely associated with tumor progression and poor prognosis, making it a recognized target for cancer therapy. This review introduces the role and mechanism of YBX1 in tumor progression, its function in embryonic development, bone differentiation, cartilage formation, and adipogenesis, the impact of upstream regulatory factors on its function, as well as the relationship between YBX1 and disease prognosis and treatment outcomes. This review aims to provide a comprehensive perspective on the function of YBX1.
Keywords: YBX1, Tumor metastasis, chemotherapy resistance, RNA Stability, Non-coding RNA interactions
Received: 26 May 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Zheng, Zeng, Lei, Yanling, Deng, Luo, He and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanhong Zhou, Central South University, Changsha, China
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