CASE REPORT article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1637847
This article is part of the Research TopicAdvancements in Antibody-Based Immunotherapy and Cancer Vaccines for Hepatocellular CarcinomaView all 9 articles
Atezolizumab-induced Vanishing Bile Duct Syndrome: a case report
Provisionally accepted
Antonio David Lázaro Sánchez1*
Carlos Tomás Noblejas Quiles2José Antonio Macías Cerrolaza2
Javier David Benitez Fuentes3Laura López Gómez2Manuel Sánchez Cánovas2María Nevado Rodríguez2Miguel Martín Cascón2Isabel Vigueras Campuzano2María Asunción Chaves Benito2- 1Hospital General Universitario Morales Meseguer, Murcia, Spain
- 2Hospital General Universitario Jose M Morales Meseguer, Murcia, Spain
- 3Hospital General Universitario de Elche, Elche, Spain
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This manuscript fits within the scope of the selected journal and specialty as it presents the first documented case of atezolizumab-induced vanishing bile duct syndrome, a rare and severe immune-mediated adverse event associated with immune checkpoint inhibitors. Given the journal's focus on oncology and immunotherapy, this case brings new perspectives to the field of oncology pharmacovigilance, highlights the clinical relevance of immuno-mediated hepatobiliary toxicity and underlines the importance of multidisciplinary treatment in immuno-oncology.
Keywords: Conceptualization, investigation, methodology, supervision, Validation, visualization, Writing -original draft, Writing -review & editing. Carlos Tomás Noblejas Quiles: Conceptualization
Received: 29 May 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Lázaro Sánchez, Noblejas Quiles, Macías Cerrolaza, Benitez Fuentes, López Gómez, Sánchez Cánovas, Nevado Rodríguez, Martín Cascón, Vigueras Campuzano and Chaves Benito. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Antonio David Lázaro Sánchez, Hospital General Universitario Morales Meseguer, Murcia, Spain
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