CASE REPORT article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1638461
Case Report and Review of the Literature: A Rare Cut -Surgical Resection of Primary CNS EBV-Positive T-Cell Lymphoma
Provisionally accepted
Lykourgos Anastasopoulos1*
Eirini Charalampopoulou1Theodoros Argyrakos2Stefanos Korfias1Fotis Bourlogiannis1- 11st University Department of Neurosurgery, General Hospital of Athens Evangelismos, Athens, Greece
- 2Department of Pathology, General Hospital of Athens Evangelismos, Athens, Greece
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With this report we share a rare and clinically challenging case of EBV-positive primary CNS T-cell lymphoma, a subtype that's often overlooked due to its atypical presentation and poor response to standard therapies. By combining detailed clinical insights with a focused review of the literature, it contributes meaningful discussion on the evolving role of surgery in managing such cases. We believe this case and the broader context it provides will be of strong interest to readers focused on neuro-oncology, CNS lymphomas, and complex neurosurgical decision-making.
Keywords: primary cns lymphoma, T-cell lymphoma, EBV-positive lymphoma, corticosteroid-refractory, Gross total resection, PCNS-TCL, EBER in situ hybridization
Received: 30 May 2025; Accepted: 28 Jul 2025.
Copyright: © 2025 Anastasopoulos, Charalampopoulou, Argyrakos, Korfias and Bourlogiannis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lykourgos Anastasopoulos, 1st University Department of Neurosurgery, General Hospital of Athens Evangelismos, Athens, Greece
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