CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1639109
This article is part of the Research TopicEvolving Therapies in Gynecological Oncology: From Chemotherapy to Personalized MedicineView all 3 articles
Early Detection and Management Strategies for isolated splenic Metastasis in Cervical Cancer:A Case Report
Provisionally accepted
- Chongqing University Cancer Hospital, Chongqing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
A 55-year-old woman experienced two months of vaginal bleeding after intercours e. After gynecological examination, cervical biopsy, and imaging examinations includin g magnetic resonance imaging (MRI) and positron emission tomography/computed tom ography (PET/CT), she was diagnosed with stage IIB cervical squamous cell carcinom a, which was associated with human papillomavirus (HPV) infection.The patient subse quently underwent robotic-assisted para-aortic lymphadenectomy, and the pathology res ults showed no evidence of cancer spread. She completed a treatment plan that includ ed chemoradiotherapy, delivering a total radiation dose of 93.2 Gy along with concurr ent cisplatin chemotherapy. Although a post-treatment evaluation indicated a partial re mission(PR), follow-up imaging revealed unusual findings in the spleen, which were l ater confirmed to be metastatic cancer. The patient underwent laparoscopic splenectom y, and the postoperative pathology confirmed the presence of squamous cell carcinoma metastasis. Genetic testing identified multiple somatic mutations and a high mutation burden in the tumor. After surgery, she received chemotherapy and targeted therapy. A t present, her condition is stable, and she has survived for 12 months. This case high lights the complex nature of cervical cancer metastasis and the important role of gene tic testing in developing personalized treatment plans.
Keywords: cervical cancer, Spleen metastasis, Splenectomy, chemotherapy, targeted therapy
Received: 01 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Na Zhang, Chongqing University Cancer Hospital, Chongqing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.