ORIGINAL RESEARCH article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1639250
Risk Factors for Thrombotic Events in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms: A Retrospective Analysis of 336 Cases
Provisionally accepted
- The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Thrombotic events are one of the main factors affecting the survival of patients with Philadelphia chromosome-negative (Ph-) myeloproliferative neoplasms (MPNs). Therefore, a comprehensive understanding of the early relevant high-risk factors makes sense for early prevention and reducing mortality in these patients. In this study, we conducted a retrospective analysis of 336 patients with Ph-MPN and summarized the clinical characteristics, incidence of thrombotic events and influencing factors. Thrombotic events occurred in 27.7% (93/336) of patients. Among the thrombotic events, arterial thrombosis occurred in 86 cases (92.5%), the most common thrombotic event was cerebral infarction (69/93, 74.2%). Univariate analysis and logistic regression identified that diagnosis of Polycythemia Vera (PV) / Essential Thrombocythemia (ET), thrombotic events before diagnosis and D-dimer≥1mg/L were the independent risk factors for thrombotic events at initial diagnosis in MPN patients (P<0.05). Receiver operating characteristic (ROC) curve analysis revealed that the integrated predictive efficacy of the triple-variable combination was markedly superior to that of any single parameter alone, yielding a sensitivity of 72.04% (95% CI: 61.8%-80.9%), a specificity of 74.49% (95% CI: 68.5%-79.8%), and an area under the curve (AUC) of 0.771 (95% CI: 0.723-0.815). Additionally, univariate analysis further identified smoking history, elevated hemoglobin (Hb≥136g/L), hematocrit (HCT≥0.42), D-dimer-to-fibrinogen ratio (DFR≥0.243) and JAK2 V617F mutation as potential risk factors for thrombosis (P<0.05), necessitating validation in future studies. These findings facilitate the early identification of Ph-MPN patients at heightened risk for thrombotic events, enabling the implementation of targeted prophylactic strategies to mitigate thrombotic risk.
Keywords: Myeloproliferative neoplasms, thrombotic events, Clinical Characteristics, Risk factors, retrospective analysis
Received: 01 Jun 2025; Accepted: 19 Aug 2025.
Copyright: © 2025 Zhang, WANG, Yang, Zi, Zhang, Guo, Lv, Wu and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Huang, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.