CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1640099
This article is part of the Research TopicBlending Pathology and Immunology - New FrontiersView all articles
Spleen EBV-positive Inflammatory Follicular Dendritic Cell Sarcoma: A Case Report and Literature Review
Provisionally accepted
Yi Xiao1
Lanlan Li1Xiumei Zhan1Juner Xu1Yewu Chen1
Qiuchan Zhao2Yinghao Fu2Xian Luo2Huadi Chen1*Hao Xu1*- 1Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
- 2Guangdong Medical University, Zhanjiang, China
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Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma (EBV+ IFDCS) is a rare tumor that typically arises in the liver or spleen and is characterized by spindle-shaped cells within a dense lymphoplasmacytic background. We report a case of a 64-year-old woman with an incidental splenic mass found during routine imaging. MRI showed a 4.8 cm lesion with progressive enhancement. The patient underwent laparoscopic partial splenectomy. Histopathological examination revealed features consistent with EBV+ IFDCS, including positivity for CD21, CD23, CD35, SMA, EMA, and EBER. EBV+ IFDCS often presents with nonspecific symptoms and imaging findings, making diagnosis challenging. Definitive diagnosis relies on histology, immunohistochemistry, and confirmation of EBV infection. Most cases follow an indolent clinical course and have a favorable prognosis after complete surgical resection, though rare aggressive cases have been reported. Understanding its clinicopathological and molecular features is essential for accurate diagnosis and management.
Keywords: Epstein-Barr virus-positive inflammatory follicular dendritic cell sarcoma, Spleen, Inflammatory tumor, Laparoscopic partial splenectomy, case report
Received: 03 Jun 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Xiao, Li, Zhan, Xu, Chen, Zhao, Fu, Luo, Chen and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huadi Chen, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
Hao Xu, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
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