CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1641188
Case Report: A rare hyperplastic polyp with synchronous high-grade intraepithelial neoplasia in both glandular and squamous epithelium in autoimmune gastritis
Provisionally accepted
- 1Departments of Gastroenterology, Zhejiang university school of medicine affiliate sir run run shaw hospital, Hangzhou, China
- 2School of Medicine, Shaoxing University, Shaoxing, Zhejiang 312000, China
- 3Department of surgery, Zhejiang university school of medicine affiliate sir run run shaw hospital, Hangzhou, China
- 4Department of Pathology, Zhejiang university school of medicine affiliate sir run run shaw hospital, Hangzhou, China
- 5Zhejiang University School of Medicine, Hangzhou, China
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A 68-year-old man came to evaluate a gastric polyp discovered during a routine gastroscopy. After endoscopic mucosal resection, pathological findings confirmed that it's a hyperplastic polyp. Notably, squamous metaplasia was observed within the hyperplastic polyp, and both squamous and glandular epithelium exhibited high-grade intraepithelial neoplasia. Besides, the diagnosis of autoimmune gastritis was established by comprehensive assessment including gastric endoscopic findings, histopathological examination and serological studies. The patient experienced no postoperative discomfort and had oral medication for two weeks. In this paper, we presents a first case worldwide of hyperplastic polyp with synchronous high-grade intraepithelial neoplasia in both glandular and squamous epithelium in autoimmune gastritist. In previous cases, the occurrence of hyperplastic polyps with neoplastic transformations or squamous metaplasia is very rare, but what we found this time was the concurrance of both lesions on hyperplastic polyps. This extremely rare case not only provides further clinical evidence for the metaplasia and neoplastic transformation potential of hyperplastic polyps, but also highlights the necessity of regular follow-up examination for autoimmune gastritis -a well-established precancerous condition.
Keywords: Autoimmune gastritis, Hyperplastic polyp, Squamous epithelium, High-grade intraepithelial neoplasia, Precancerous condition
Received: 04 Jun 2025; Accepted: 16 Jul 2025.
Copyright: © 2025 Zhang, Chen, Hendi, Tang, Tan, Liu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weiling Hu, Departments of Gastroenterology, Zhejiang university school of medicine affiliate sir run run shaw hospital, Hangzhou, China
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