Yaming Lv1,2†
Yunhui Zhang
Yajie Hu- 1Department of Respiratory Medicine, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China
- 2Department of Respiratory Medicine, The First People’s Hospital of Yunnan Province, Kunming, China
- 3Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming, China
A Correction on
circDENND4C serves as a sponge for miR-200b to drive non-small cell lung cancer advancement by regulating MMP-9 expression
By Lv Y, Wang L, Zhang Y, Wei D and Hu Y (2025) Front. Oncol. 15:1441384. doi: 10.3389/fonc.2025.1441384
There was a mistake in Figure 5B and Figure 6B as published. In Figure 5B, due to the author’s unintentionally arranged error, the flow cytometry image of apoptosis results of the miR-200b-Knockdown group was incorrected as the image of the Mock group. In Figure 6B, due to the author adopted the same photoing techniques to obtain many high quality pictures for the migration and invasion experiments, the original picture sources of the Plasmid-Control group and the miR-200b-Over group were unintentionally misused when the author selected the photos and arranged them. The corrected [Figure 5B and Figure 6B] and its caption “Figure 5B Flow cytometry was used to analyze the apoptotic rate of A549 cells transfected with the overexpression and knockdown vectors of circDENN4C, miR-200b and MMP-9. The data are presented as the mean ± SEM.” and “Figure 6B The invasion of A549 cells transfected with the indicated vectors was assessed by transwell invasion assay. The data are presented as the mean ± SEM.” appear below.
Figure 5. Influences of the circDENND4C/miR-200b/MMP-9 regulatory axis on cell cycle and cell death of A549 cells. (A) Flow cytometry was used to analyze the cell cycle in A549 cells transfected with the overexpression and knockdown vectors of circDENN4C, miR-200b, and MMP-9. (B) Flow cytometry was used to analyze the apoptotic rate of A549 cells transfected with the overexpression and knockdown vectors of circDENN4C, miR-200b and MMP-9.The data are presented as the mean ± SEM. The p-values at the bottom of the bar chart are obtained by ANOVA among multiple groups, while the NS and detailed p-values labeled in the bar chart are the results of post-ANOVA comparison. NS, not significant.
Figure 6. The circDENND4C/miR-200b/MMP-9 axis regulated NSCLC cell migration and invasion. (A) The migration of A549 cells transfected with the indicated vectors was assessed by the transwell migration assay. (B) The invasion of A549 cells transfected with the indicated vectors was assessed by transwell invasion assay. The data are presented as the mean ± SEM. The p-values on the right side of the bar chart are obtained by ANOVA among multiple groups, while the detailed p-values labeled in the bar chart are the results of post-ANOVA comparison. NS, not significant.
The original article has been updated.
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Keywords: circDENND4C, miR-200b, MMP-9, non-small cell lung cancer (NSCLC), tumor progression
Citation: Lv Y, Wang L, Zhang Y, Wei D and Hu Y (2025) Correction: circDENND4C serves as a sponge for miR-200b to drive non-small cell lung cancer advancement by regulating MMP-9 expression. Front. Oncol. 15:1641204. doi: 10.3389/fonc.2025.1641204
Received: 04 June 2025; Accepted: 04 August 2025;
Published: 02 September 2025.
Edited and reviewed by:
Cecilia Ana Suarez, National Scientific and Technical Research Council (CONICET), ArgentinaCopyright © 2025 Lv, Wang, Zhang, Wei and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Dong Wei, bWRoaXdlaWRvbmdAc2luYS5jb20=; Yajie Hu, aHV5YWppZTg4MDIxN0AxNjMuY29t
†These authors have contributed equally to this work