SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1642833
This article is part of the Research TopicBladder Cancer Awareness Month 2025: Current Developments and Insights in the Treatment of Bladder CancerView all 4 articles
Prevalence and prognostic value of sarcopenia in patients with bladder cancer undergoing radical cystectomy: A systematic review and meta-analysis
Provisionally accepted
- The People's Hospital of Leshan, Leshan, China
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Background: The relationship between sarcopenia and clinical outcomes in patients with bladder cancer (BC) has been inconsistently reported in the literature. Some studies have identified sarcopenia as a potential prognostic indicator associated with reduced survival following radical cystectomy (RC). Objectives: This study was conducted to systematically evaluate the prognostic significance of sarcopenia in patients with bladder cancer undergoing RC. Design: Systematic review and meta-analysis. Methods: We conducted a comprehensive search of multiple databases, including PubMed, EMBASE, Web of Science, Cochrane Library, CHINAHL, China National Knowledge Infrastructure (CNKI) Databases, and Wanfang Database, up to August 23, 2023, to identify both retrospective and prospective cohort studies. To assess the methodological quality of the included studies, the Newcastle-Ottawa Scale was utilized to evaluate the risk of bias. Furthermore, heterogeneity and potential publication bias were examined, and both subgroup and sensitivity analyses were performed to ensure the robustness of the findings. Results: A total of 18 studies comprising 3,110 patients were included in the quantitative synthesis. The results of meta-analysis showed that the pooled prevalence of sarcopenia was estimated to be 49% (95% CI: 41% to 57%, I2 = 95.3%, P < 0.001), which was based on a random-effects model.We observed that BC patients with sarcopenia had a worse OS (HR:1.64, 95% CI: 1.30 to 1.97, I2 = 76.5%, P < 0.001} and CSS (HR:1.86, 95% CI: 1.45 to 2.27, I2 = 0.0%, P < 0.001). Conclusion Sarcopenia is commonly observed among patients with bladder cancer and appears to be an important prognostic indicator associated with decreased OS and CSS in those undergoing radical cystectomy. Further prospective studies are warranted to validate these findings.
Keywords: Sarcopenia, Bladder cancer, Radical cystectomy, prognosis, Meta-analysis
Received: 24 Jun 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Lei, Fanmin, Lemei, Jianjia and Xiye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhang Lei, The People's Hospital of Leshan, Leshan, China
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