ORIGINAL RESEARCH article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1643239
This article is part of the Research TopicTranslational Strategies for Chronic Lung Diseases: Emerging Therapies and Precision MedicineView all 6 articles
Bronchoscopic intervention in the management of primary tracheobronchial adenoid cystic carcinoma with dyspnea
Provisionally accepted
- Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Primary tracheobronchial adenoid cystic carcinoma (TACC) is a rare, slow-progressing malignant tumor whose airway obstruction frequently compromise survival. This study aimed to investigate the value of interventional bronchoscopy in TACC. Methods: We retrospectively analyzed the clinical data of TACC patients treated between January 2006 and December 2024. 52 patients were stratified into two groups: the bronchoscopic intervention alone group (n = 25) and combined therapy group (n = 27). Kaplan-Meier methodology was employed to estimate median progression-free survival (PFS), overall survival (OS), and survival rates. Prognostic factors were further evaluated using Cox proportional hazards model. Results: The mean age of 52 TACC patients was 51.77 ± 14.40 years. Bronchoscopic intervention demonstrated significant reduction in mMRC score and Freitag grade (P < 0.01). Median PFS and OS were 20 months and 118 months, respectively. The 3-/5-/10-year OS were 80.00%, 69.12%, and 34.87%. The combined therapy group exhibited superior PFS compared to the bronchoscopic intervention alone group (P < 0.05). Cox analysis identified combined therapy and stenosis degree as independent prognostic factors for PFS (P < 0.05). Conclusions: Bronchoscopic intervention demonstrated significant efficacy in alleviating dyspnea and airway stenosis while sustaining long-term survival in TACC patients. Multimodal therapy showed potential advantages provided incremental benefits in delaying disease progression.
Keywords: Tracheobronchial adenoid cystic carcinoma, Bronchoscopic intervention, Airway stenosis, Progression-free survival, overall survival
Received: 20 Jun 2025; Accepted: 28 Aug 2025.
Copyright: © 2025 Wu, Qiu, Jin, Niu, Jin, Bu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaoning Bu, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Juan Wang, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.