ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1644317
This article is part of the Research TopicNational Cancer Research Month 2025: Advances in Detection, Treatment and Therapies in OncologyView all 13 articles
Isolated hypoxic pelvic perfusion combined with electroporation is a valid alternative to traditional therapies for anal squamous cell carcinoma. A case study
Provisionally accepted
- 1Department of Surgical Oncology, MEDIAS Burghausen Clinic, Burghausen, Germany
- 2Department of Tumor Biology, MEDIAS Burghausen Clinic, Burghausen, Germany
- 3Department of Anesthesiology, MEDIAS Burghausen Clinic, Burghausen, Germany
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Introduction: We report a series of four patients with HPV-positive squamous cell carcinoma of the anus: two with non-previously treated grade G3 malignancies, and two with relapsing G2 tumors in progression after chemoradiation. Method: Chemo-naive patients were treated with isolated hypoxic pelvic perfusion, whereas the two patients with local recurrences both received isolated hypoxic pelvic perfusion and concomitant reversible electroporation. Results: The two patients without prior therapy showed a complete clinical and pathological response, one after two and one after three therapies. In the two patients with local recurrences, a clinico-pathological complete remission occurred after two isolated perfusions with electroporation. The two techniques combined produce highly effective drug exposure that leads to complete remission; subsequent blood purification by chemofiltration avoids toxic side effects and cumulative toxicity. The therapies caused no side effects affecting quality of life. No recurrences occurred in the observation period of 48, 27, 10 and 8 months. Conclusion: Isolated hypoxic pelvic perfusion with electroporation is an effective, low-toxicity valid alternative to traditional therapies for the treatment of anal squamous cell carcinoma.
Keywords: Gastrointestinal Cancers: Colorectal Cancer Conceptualization, Formal analysis, investigation, methodology, supervision, Validation, Writing -original draft, Writing -review & editing. Kornelia Aigner: Methodology
Received: 26 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Aigner, Aigner, Hendrikx, Bekrentchir and Aust. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Karl Reinhard Aigner, Department of Surgical Oncology, MEDIAS Burghausen Clinic, Burghausen, Germany
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