CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1647218
This article is part of the Research TopicReal-World Clinical and Translational Research in Gastrointestinal CancersView all 19 articles
Effectiveness of Inetetamab Combined with Immunochemotherapy as First-Line Treatment in Two Cases of Advanced Gastric Cancer with HER2 Expression: A Retrospective Analysis
Provisionally accepted
- 1National University of Singapore, Singapore, Singapore
- 2People's Hospital Affiliated to Nankai University of Tianjin, Tianjin, China
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This retrospective study analyzed the effectiveness of Inetetamab combined with an immunochemotherapy regimen as first-line treatment in two cases of advanced gastric cancer with human epidermal growth factor receptor 2 (HER2) expression. Both patients were elderly males diagnosed with gastric cancer presenting with distant metastasis at initial diagnosis. They were treated with a combination of Inetetamab, Tislelizumab, and the XELOX regimen (Inetetamab 300mg administered on Day 1; Tislelizumab 200mg administered on Day 1; Oxaliplatin 150mg administered on Day 2; Capecitabine 1.5g orally twice daily on Days 1-14; repeated every 3 weeks per cycle). Efficacy evaluation revealed that both patients achieved a partial response (PR). They attained progression-free survival (PFS) durations of 10 to 12 months. Treatment was well-tolerated throughout, with no occurrence of grade 3-4 adverse events. This therapeutic regimen provided significant survival benefits for these patients with advanced, multiply metastatic, HER2-positive gastric cancer. The findings of this study suggest a novel first-line treatment strategy for advanced gastric cancer, potentially improving treatment efficacy and quality of life for HER2-positive gastric cancer patients. Nevertheless, further clinical trials are warranted to validate the efficacy and safety of this treatment approach.
Keywords: HER2-positive gastric cancer, inetetamab, partial response (PR), Safety and efficacy, immunochemotherapy
Received: 15 Jun 2025; Accepted: 14 Oct 2025.
Copyright: © 2025 Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shan Wu, e0204984@u.nus.edu
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