EDITORIAL article
Front. Oncol.
Sec. Cancer Metabolism
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1647690
This article is part of the Research TopicMetabolism, Gut Microbiome, and CancerView all 12 articles
Editorial: A Converging Topic "Metabolism, Gut Microbiome, and Cancer"
Provisionally accepted
- 1Nutrition and Food Science, University of Maryland, College Park, College Park, AL, United States
- 2The University of Alabama at Birmingham, Birmingham, United States
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This research topic entitled "Metabolism, Gut Microbiome, and Cancer" in Frontiers in Oncology has collected ten scholarly articles that reflect the latest advances in this interdisciplinary field. Collectively, this collection provides new insights into the complex interrelationships between host metabolism and the gut microbiome in cancer biology. It also highlights promising targets for future therapeutic interventions aimed at modulating microbial and metabolic pathways to improve cancer prevention and treatment.The gut microbiome affects the efficacy and treatment outcomes of cancer chemotherapy.bladder cancer treatment outcomes. Researchers have identified the enriched presence of certain bacterial species, such as Granulicatella and Proteus, in patients who did not respond to neoadjuvant chemotherapy, while E. faecalis was more prevalent in the responders, suggesting that specific microbial profiles may affect chemotherapeutic efficacy. Additionally, this study revealed that some bacteria within the urinary microbiome can metabolize gemcitabine, a common chemotherapy agent for bladder cancer, potentially reducing its effectiveness. This finding highlights the importance of individualized microbial compositions that help develop personalized treatment strategies for bladder cancer patients.Metabolic reprogramming is considered as a hallmark of cancer progression and metastasis featured by abnormalities in glucose, glutamine and lipid metabolism. In a review article, Lu et al. In summary, the ten articles in this Research Topic highlight the multifaceted roles of the gut microbiome and metabolome in cancer biology. They emphasize the potential of targeting microbial communities and metabolomic outputs as part of integrated cancer prevention and treatment strategies. Importantly, these findings underscore a growing recognition that cancer is not solely a genetic disease but one deeply influenced by complicated interactions between host microbes and metabolic environment. As such, incorporating microbiome and metabolomic profiling into precision oncology could lead to more personalized, responsive interventions.Continued interdisciplinary research that bridges oncology, microbiology, systems biology, and metabolomics holds great promise for unveiling novel mechanisms of tumorigenesis and unlocking new therapeutic and diagnostic pathways for cancer patients.The authors declare no potential conflicts of interest.
Keywords: gut microbiome, Metabolism, Metabolites, Cancer, immune, targeted therapy, prevention, tumorigenesis
Received: 16 Jun 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Li and Tollefsbol. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuanyuan Rose Li, Nutrition and Food Science, University of Maryland, College Park, College Park, 35294-1170, AL, United States
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