ORIGINAL RESEARCH article
Front. Oncol.
Sec. Skin Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1649387
This article is part of the Research TopicGenetics and Epigenetics of Melanoma and Non-Melanoma Skin CancerView all 6 articles
Somatic Gene Variation Profiles in Geriatric and Adult Malignant Melanoma Patients
Provisionally accepted
Busra EkinciIbrahim Halil Erdogdu
Seda Orenay-Boyacioglu
Olcay Boyacioglu*
Nesibe Kahraman-CetinDilara AkinMerve TuranCanten Tataroglu- Aydin Adnan Menderes Universitesi, Aydın, Türkiye
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Abstract Introduction: Skin cancer is a highly heterogeneous disease affecting substantial geriatric individuals. Therefore, understanding gene variants and their presence in geriatric and adult skin cancer patient groups is valuable for the improvement of healthcare policies. The somatic variation profile in geriatric patients diagnosed with malignant melanoma (MM) was examined retrospectively by comparing them to the younger cases to reveal the clinical importance of the panel tests. Methods: The study included all adult MM patients referred to Molecular Pathology Laboratory from Oncology Clinic between 2019 and 2023. The patients (n=103) were chronologically divided into geriatric (≥65) and adult (<65 years) groups. The results of targeted next generation sequencing panel studied with probe-capture method were evaluated retrospectively. Results: Among the study cohort, 58 (56.31%) were male, 45 (43.69%) were female, and also 55 were in the geriatric age group, 48 were in the adult group with an overall mean age of 63.30 years. The most commonly encountered pathogenic variants in the geriatric MM group were BRAF V600E (14.55%) and V600K (7.27%) variants in Exon 15 followed by NRAS (9.09%), NF1 (9.09%), KIT (5.45%), KRAS (5.45%), CDKN2A (3.64%), and PTEN (3.63%). In the adult MM group, the most common pathogenic variants were BRAF V600E (39.58%) and V600K (8.33%) followed by NRAS (14.58%), NF1 (8.33%), PTEN (8.33%), BRCA2 (8.33%), and TP53 (4.17%). Conclusions: Delineating the distribution of somatic variations in geriatric MM cases holds significant importance in the development of healthcare policies. These data are the first reported findings from Türkiye.
Keywords: genetic variants, Geriatrics, malignant melanoma, NGS, somatic mutation
Received: 18 Jun 2025; Accepted: 26 Sep 2025.
Copyright: © 2025 Ekinci, Erdogdu, Orenay-Boyacioglu, Boyacioglu, Kahraman-Cetin, Akin, Turan and Tataroglu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Olcay Boyacioglu, oboyaci@adu.edu.tr
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