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CASE REPORT article

Front. Oncol.

Sec. Neuro-Oncology and Neurosurgical Oncology

TREATMENT CHALLENGES IN GLIOBLASTOMA – A CASE REPORT

Provisionally accepted
Roda DomingosRoda Domingos1Filipa OliveiraFilipa Oliveira2Pedro VeigaPedro Veiga2Leonor SantosLeonor Santos3Pedro AbreuPedro Abreu4Ana NascimentoAna Nascimento4Francisco José CarameloFrancisco José Caramelo2Joana B MeloJoana B Melo2Isabel CarreiraIsabel Carreira2Ilda Patrícia RibeiroIlda Patrícia Ribeiro2*
  • 1Joaquim Chaves Saúde (JCS), Faro, Portugal, Faro, Portugal
  • 2University of Coimbra, Coimbra, Portugal
  • 3Unidade Local de Saude de Coimbra, Coimbra, Portugal
  • 4Unidade Local de Saude do Algarve, Faro, Portugal

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This clinical case report aims to show the survival timeline of a glioblastoma patient who underwent surgery and received adjuvant treatments in accordance with the Stupp protocol. Starting on the day of surgery, liquid biopsy was employed to assess the dynamic alterations in cell-free DNA (cfDNA). Upon recurrence, reoperation was conducted, and repeated radio-chemotherapy was applied. This clinical case is interesting due to the doubling extendedof the average survival time, despite the extremely aggressive nature of the medical interventions. Liquid biopsies constitute a non-invasive method of characterising circulating tumour DNA (ctDNA) and evaluating genetic and epigenetic modifications, providing considerable potential for tumour diagnosis, prognosis, and management.

Keywords: Glioblastoma, liquid biopsies, Circulating tumour DNA, Genetic and epigenetic signature, Copy number alterations

Received: 22 Jun 2025; Accepted: 25 Nov 2025.

Copyright: © 2025 Domingos, Oliveira, Veiga, Santos, Abreu, Nascimento, Caramelo, Melo, Carreira and Ribeiro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ilda Patrícia Ribeiro

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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