ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1652621
This article is part of the Research TopicRNA Methylation and Demethylation in Tumorigenesis and as Therapeutic TargetsView all 7 articles
Dynamic Alterations in m⁶A RNA Methylation Profiles during Involution of Infantile Hemangiomas
Provisionally accepted
- Department of Laser and Aesthetic Medicine, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital Department of Radiotherapy, Shanghai, China
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Infantile hemangioma (IH) is a common benign vascular tumor characterized by a proliferative phase followed by regression. N6-methyladenosine (m6A) methylation, a major RNA modification, plays a critical role in tumor development, though its function in IH remains unclear. This study analyzed six IH samples (three from proliferative IH, three from involuting IH), using transcript-specific microarrays after m6A immunoprecipitation to explore dynamic methylation changes and their regulatory impact on gene expression. Results showed significantly lower m6A levels in involuting-phase hemangiomas. Differentially methylated genes (DMGs) were mainly involved in biological processes such as cell-cell junction and cellmatrix adhesion. KEGG pathway analysis revealed DMGs were enriched in MAPK, Calcium, and PI3K-Akt signaling pathways, suggesting that m6A modifications are closely linked to angiogenesis and tumor growth. MeRIP-qPCR showed that IGF1 and IGF2 exhibiting significant correlation in both m6A levels and expression. The overall downregulation of m6A modification f lncRNA and sncRNA suggested active demethylation processes may involve in involution of IH. Overall, this study demonstrates that m6A methylation modulates key cellular pathways in IH progression and may serve as a promising target for future diagnostic and therapeutic strategies.
Keywords: infantile hemangioma, m6A methylation, Proliferative phase, Involuting Phase, RNA modification
Received: 24 Jun 2025; Accepted: 13 Aug 2025.
Copyright: © 2025 Wu, Cen, Shang, Liang and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gang Ma, Department of Laser and Aesthetic Medicine, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital Department of Radiotherapy, Shanghai, China
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