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ORIGINAL RESEARCH article

Front. Oncol.

Sec. Radiation Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1652684

This article is part of the Research TopicInnovative Approaches in Precision Radiation OncologyView all 19 articles

An Innovative Hippocampal-Sparing Whole-Brain Radiotherapy Planning Approach via the Halcyon System: Achieving Lower Hippocampal Doses

Provisionally accepted
Ran TangRan Tang1,2Maoying Lan C#Maoying Lan C#3Sun XingruSun Xingru2Yue LuoYue Luo4Anyan GuAnyan Gu2Qing LiuQing Liu5Yingjing LiYingjing Li6Guozi YangGuozi Yang2Zhenyu PanZhenyu Pan2Guanhua DengGuanhua Deng7*
  • 1Nanchang University School of Public Health, Nanchang, China
  • 2Department of Radiation Oncology, Huizhou Third People’s Hospital, Guangzhou Medical University, Huizhou, China
  • 3Department of Radiation Oncology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
  • 4Department of Radiation Oncology, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China
  • 5People’s Hospital of Shaodong, Shaoyang, China
  • 6Nanjing Tongrentang Chinese Medicine, Huizhou, China
  • 7Department of Radiation Oncology, Guangdong Provincial People's Hospital, Guangzhou, China

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Objective: To evaluate the feasibility and dosimetric benefits of Halcyon-based coplanar dual-arc volumetric modulated arc therapy (VMAT) for hippocampal-avoidance whole brain radiotherapy (HA-WBRT).: Twenty-one HA-WBRT patients were replanned using dual-arc VMAT (collimator 23°/293°) on Halcyon and Truebeam. The planning target volume (PTV) was segmented into three substructures and optimized with different weight parameters. Dosimetric parameters of PTV, monitor units (MUs), does to organs-at-risk(OARs), hippocampal normal tissue complication probability (NTCP) and gamma passing rate were recorded. Results: All plans met RTOG 0933 criteria. The Halcyon plans demonstrated significantly better homogeneity index (HI) and V30Gy of the PTV (HI: 0.105 vs. 0.121, P<0.001; V30Gy: 97.1% vs. 96.3%,

Keywords: Halcyon, Hippocampus, Whole brain radiotherapy, volumetric modulated arc therapy, treatment planning

Received: 24 Jun 2025; Accepted: 20 Aug 2025.

Copyright: © 2025 Tang, Lan C#, Xingru, Luo, Gu, Liu, Li, Yang, Pan and Deng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Guanhua Deng, Department of Radiation Oncology, Guangdong Provincial People's Hospital, Guangzhou, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material