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CORRECTION article

Front. Oncol., 25 July 2025

Sec. Thoracic Oncology

Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1653197

This article is part of the Research TopicTailored Strategies for Lung Cancer Diagnosis and Treatment in Special PopulationsView all 9 articles

Correction: CT-based radiomics integrated model for brain metastases in stage III/IV ALK-positive lung adenocarcinoma patients

This article is a correction to:

  1. CT-Based Radiomics Integrated Model for Brain Metastases in Stage III/IV ALK-positive Lung Adenocarcinoma Patients

    1. Read original article
Fen Wang&#x;Fen Wang1†Caiyun Li&#x;Caiyun Li2†Shuke Li&#x;Shuke Li3†Teng ZhangTeng Zhang4Tongfu YuTongfu Yu4Wei ZhangWei Zhang4Jing HeJing He3Mei Yuan*Mei Yuan4*Wen Gao*Wen Gao3*
  • 1Department of Medical Imaging, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, China
  • 2Department of Radiology, First Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
  • 3Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
  • 4Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

A Correction on
CT-based radiomics integrated model for brain metastases in stage III/IV ALK-positive lung adenocarcinoma patients

By Wang F, Li C, Li S, Zhang T, Yu T, Zhang W, He J, Yuan M and Gao W (2025). Front. Oncol. 15:1585930. doi: 10.3389/fonc.2025.1585930

There was a mistake in the caption of Figure 7 as published. The Rad_score threshold was computed using the surv_cutpoint function not Xtile, which was mistakenly attributed to wrong reference. Upon rechecking the sources, we confirmed that the correct citation should be Xi J, Yin J, Liang J, Zhan C, Jiang W, Lin Z, et al. Prognostic Impact of Radiological Consolidation Tumor Ratio in Clinical Stage IA Pulmonary Ground Glass Opacities. Front Oncol. (2021)12;11:616149. doi: 10.3389/fonc.2021.616149. The corrected legend appears below.

Figure 7
Panel A displays a graph showing the distribution of the Rad_score with a cutpoint at 0.2. Panel B illustrates a survival curve for the training cohort, distinguishing between high-risk and low-risk groups, with a significant log-rank p-value below 0.0001. Panel C presents a survival curve for the validation cohort, showing separation between risk groups, with a log-rank p-value of 0.0007. Panel D shows a survival curve for the external test cohort with no significant difference between groups, indicated by a log-rank p-value of 0.13.

Figure 7. The Rad_score threshold (0.20) was computed by surv_cutpoint function for dividing patients into high- and low-risk groups (A). The Kaplan-Meier cumulative event curve for survival status shows that the patients in the low-risk group showed significantly better PFS compared to those in the high-risk group in the training cohort (B) and validation cohort (C), whereas the survival difference between the low- and high-risk groups was not statistically significant in the external test cohort (D). But the longer medial survival was seen in the low-risk group than those in the high-risk group in three cohorts.

“The Rad_score threshold (0.20) was computed by surv_cutpoint function for dividing patients into high- and low-risk groups (A). The Kaplan-Meier cumulative event curve for survival status shows that the patients in the low-risk group showed significantly better PFS compared to those in the high-risk group in the training cohort (B) and validation cohort (C), whereas the survival difference between the low- and high-risk groups was not statistically significant in the external test cohort (D). But the longer medial survival was seen in the low-risk group than those in the high-risk group in three cohorts”.

Furhtermore, the reference for (38) was incorrectly written as “Li Y, Zhao J, Li R, Yao X, Dong X, Zhao Y, et al. Predicting prognosis in patients with stage IA lung adenocarcinoma with a micropapillary component using a nomogram based on computed tomography radiomics and clinicopathologic factors: a retrospective analysis. Transl Lung Cancer Res. (2024) 13:2585–602. doi: 10.21037/tlcr-24-544”. It should be “Xi J, Yin J, Liang J, Zhan C, Jiang W, Lin Z, et al. Prognostic Impact of Radiological Consolidation Tumor Ratio in Clinical Stage IA Pulmonary Ground Glass Opacities. Front Oncol. (2021)12;11:616149. doi: 10.3389/fonc.2021.616149”.

A correction has been made to Materials and methods, PFS analysis. This sentence previously stated:

“According to the cutoff of the Rad_score, participants were categorized into a high-risk group and a low risk group by Xtile (38).”

The corrected sentence appears below:

“According to the cutoff of the Rad_score, participants were categorized into high-risk and low-risk groups using the surv_cutpoint function in R survminer package (38).”

A correction has been made to Materials and methods, Statistical analysis. This sentence previously stated:

“Statistical analysis was carried out using several software, such as SPSS 25.0, R software (version 4.1.0; https://www.r-project.org), R software (version 3.3.4; https://www.r-project.org, the “carnet” and “ggplot” packages) and Python software (version 3.7.0; http://www.python.org; scikitplot, sklearn, matplotlib.pyplot, lightgbm, xgboost, sklearn.neighbors, sklearn.svm, numpy, and shap packages).”

The corrected sentence appears below:

“Statistical analysis was carried out using several software, such as SPSS 25.0, R software (version 4.1.0; https://www.r-project.org, the “carnet”,”survminer” and “ggplot” packages) and Python software (version 3.7.0; http://www.python.org; scikitplot, sklearn, matplotlib.pyplot, lightgbm, xgboost, sklearn.neighbors, sklearn.svm and numpy packages).”

A correction has been made to Results, PFS analysis. This sentence previously stated:

“The rad_score threshold (0.20) was computed with Xtile for dividing patients into high- and low-risk groups (Figure 7A)”

The corrected sentence appears below:

“The Rad_score threshold (0.20) was computed using surv_cutpoint function in R survminer package for dividing patients into high- and low-risk groups (Figure 7A)”

The original version of this article has been updated.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Keywords: lung adenocarcinoma, anaplastic lymphoma kinase, radiomics, brain metastasis, computed tomography

Citation: Wang F, Li C, Li S, Zhang T, Yu T, Zhang W, He J, Yuan M and Gao W (2025) Correction: CT-based radiomics integrated model for brain metastases in stage III/IV ALK-positive lung adenocarcinoma patients. Front. Oncol. 15:1653197. doi: 10.3389/fonc.2025.1653197

Received: 24 June 2025; Accepted: 01 July 2025;
Published: 25 July 2025.

Edited and Reviewed by:

Natsuo Tomita, Nagoya City University, Japan

Copyright © 2025 Wang, Li, Li, Zhang, Yu, Zhang, He, Yuan and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Wen Gao, Z2Fvd2VuQGpzcGgub3JnLmNu; Mei Yuan, eXVhbWVpamlhbmdzdUAxNjMuY29t

†These authors have contributed equally to this work

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.