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CASE REPORT article

Front. Oncol.

Sec. Gynecological Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1654368

This article is part of the Research TopicCutting-Edge Strategies in Screening, Prevention, and Treatment in Gynaecologic OncologyView all 11 articles

Rare Widespread Dissemination of Cervical High-grade Squamous Intraepithelial Lesion with Microinvasive Squamous Cell Carcinoma: A Case Report

Provisionally accepted
Dan  LiuDan Liu1*Shijie  LiuShijie Liu2
  • 1The First Affiliated Hospital of Dalian Medical University, Dalian, China
  • 2Dalian Women and Children's Medical Center, Dalian, China

The final, formatted version of the article will be published soon.

Background: Cervical high-grade squamous intraepithelial lesion (HSIL), a precancerous condition, can progress to cervical squamous cell carcinoma (CSCC), the most prevalent histological subtype of cervical cancer. Although CSCC most commonly metastasizes via lymphatic or hematogenous routes, contiguous superficial spread to the endometrium, fallopian tubes, and ovaries is rare.Case presentation: A 61-year-old postmenopausal woman was referred to our hospital for further evaluation after a positive HPV-16 test and normal ThinPrep Cytologic Test (TCT) results during a routine health examination at an external institution two weeks earlier. Histopathological examination of colposcopy-guided biopsies confirmed chronic cervicitis with HSIL. Notably, the serum squamous cell carcinoma antigen (SCC-Ag) level was markedly elevated (32.20 ng/mL). Transvaginal color Doppler ultrasonography revealed a cystic mass in the right pelvic region. Intraoperative laparoscopic findings included a tortuous, thickened right fallopian tube with fimbrial occlusion. Gross pathological examination revealed an irregular grayish-white endometrial lesion measuring 2.5*2.0 cm. The right fallopian tube exhibited focal dilation, measuring 1.6 cm in diameter. No gross abnormalities were detected in the right ovary. Final histopathology confirmed extensive cervical HSIL (CIN III) with multifocal stromal invasion (maximum depth: 4 mm), which involved the endometrium, right fallopian tube mucosa, and an ovarian inclusion cyst on the ipsilateral side.Cervical HSIL/SCC may exhibit superficial upward extension to the endometrium and, in rare cases, can involve the ovaries. Although rare, this clinical entity warrants increased clinical vigilance. Currently, no standardized management guidelines exist for this distinct metastatic pattern, and emerging evidence suggests a multifactorial pathogenesis. These findings underscore the need for enhanced early detection and preventive strategies.

Keywords: High-grade squamous intraepithelial lesion, Squamous cell carcinoma, Superficial spreading, Endometrium, fallopian tube, Ovary

Received: 26 Jun 2025; Accepted: 28 Jul 2025.

Copyright: © 2025 Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dan Liu, The First Affiliated Hospital of Dalian Medical University, Dalian, China

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