CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1655532
This article is part of the Research TopicCase Reports in Radiation Oncology: 2025View all 14 articles
Mimicking Benignity: Hepatic Sinusoidal Metastasis Masquerading as Diffuse Liver Disease in Small Cell Lung Cancer -A Case Report
Provisionally accepted
- 1Shaoxing People's Hospital, Shaoxing, China
- 2Shaoxing University Affiliated Hospital, Shaoxing, China
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Background: Small cell lung cancer is extremely aggressive. Although liver metastasis is common, cases of diffuse intra-sinusoidal metastasis leading to liver failure and death are quite rare.Case presentation: This paper reports a case of a 58-year-old male diagnosed with small cell lung cancer through a pathological biopsy, who died due to the rapid progression of liver failure caused by diffuse hepatic sinusoidal metastasis during subsequent treatment.Conclusions: Diffuse intra-sinusoidal liver metastasis originating from small cell lung cancer may serve as a clinically occult cause of liver failure. Such metastases progress rapidly, often leading to death within days to weeks. For patients with a history of malignant tumors, if imaging studies reveal diffuse liver lesions and rapidly progressing liver function abnormalities, there should be a high suspicion of diffuse hepatic sinusoidal metastasis. A timely liver biopsy should be performed to confirm the diagnosis, providing a theoretical basis for clinical diagnosis and treatment .
Keywords: Small Cell Lung Cancer, diffuse intrahepatic metastasis, Liver Failure, tr eatment, case report
Received: 28 Jun 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Chen, Chen, Yang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Minxia Yang, Shaoxing People's Hospital, Shaoxing, China
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