CASE REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1656034
This article is part of the Research TopicHost Features Affecting CAR T Cell Therapy of Hematological MalignanciesView all 4 articles
Successful CD19 chimeric antigen receptor T-cell therapy following autologous stem cell transplantation in a secondary central nervous system lymphoma patient with COVID-19 infection: A case report and literature review
Provisionally accepted
- The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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This paper reported a 64-year-old, secondary central nervous system lymphoma (sCNSL) patient with COVID-19 infection during CD19 chimeric antigen receptor T-cell therapy（CAR-T） following autologous stem cell transplantation（ASCT). Our findings demonstrate that the combination of ASCT and CAR-T for sCNSL may be feasible,even for SARS-CoV-2 positive immunocompromised lymphoma patients.
Keywords: Diffuse large B-cell lymphoma, Secondary central nervous system lymphoma, CD19 chimeric antigen receptor T-cell, Autologous stem cell transplantation, COVID-19
Received: 29 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Wang, ren, Wang, Luo, Li and he. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: pengcheng he, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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