CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1656841
This article is part of the Research TopicCutting-Edge Strategies in Screening, Prevention, and Treatment in Gynaecologic OncologyView all 30 articles
Endometrial Carcinosarcoma in a Young Female with Absence of Established Risk Factors: A Case Report
Provisionally accepted
- 1Tangshan People's Hospital, Tangshan, China
- 2National Innovation Center for Advanced Medical Devices Co Ltd, Shenzhen, China
- 3Central Hospital of Dalian University of Technology, Dalian, China
- 4Liaoning Cancer Hospital and Institute, Shenyang, China
- 5Other
- 6Shunyi Women's and Children's Hospital of Beijing Children's Hospital, Beijing, China
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Endometrial carcinosarcoma is a rare, aggressive uterine malignancy, usually affecting postmenopausal women with recognised risk factors such as prolonged unopposed oestrogen exposure, tamoxifen use, pelvic irradiation, or high BMI. We report a 21-year-old Chinese woman with no known risk factors who presented with persistent vaginal bleeding, anaemia, and lower abdominal pain. Investigations showed microcytic hypochromic anaemia, elevated CA125, CA153, CA199, and Human Epididymis Protein 4, and pelvic MRI revealed a malignant endometrial lesion with vaginal involvement and lymphadenopathy. Biopsy confirmed carcinosarcoma with grade 3 endometrioid carcinoma as the epithelial component. Multidisciplinary review recommended extensive laparoscopic hysterectomy with bilateral adnexectomy, lymphadenectomy, and omentectomy, followed by six cycles of paclitaxel–carboplatin chemotherapy. Histology confirmed the diagnosis, and two-year follow-up showed no recurrence; a postoperative vesicovaginal fistula was surgically repaired. This atypical case in a young, underweight woman without established risk factors challenges current epidemiological assumptions and emphasises the importance of broad diagnostic consideration, timely referral, and comprehensive management.
Keywords: endometrial carcinosarcoma, Young female, No Established Risk Factors, multidisciplinary management, case report
Received: 30 Jun 2025; Accepted: 15 Sep 2025.
Copyright: © 2025 Wei, Bai, Kong, Wang and Mi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaomin Wang, wxm701117@163.com
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