CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1656872
This article is part of the Research TopicCase Reports in Radiation Oncology: 2025View all 15 articles
A Case Report and Literature Review on Positive Outcomes Achieved through Radiotherapy in a Patient with Composite Hemangioendothelioma
Provisionally accepted
- The First Affiliated Hospital of Kunming Medical University, Kunming, China
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Background Composite hemangioendothelioma (CHE) is a rare borderline vascular neoplasm, typically characterized by a heterogeneous composition of benign, intermediate, and malignant vascular elements. Metastasis occurs occasionally, yet local recurrence remains relatively common. CHE frequently manifest in the deep dermis and subcutaneous soft tissues of the distal limbs, and are rarely observed in bone or vertebral column. We present a case that originally occurred in the lumbar spine. Case presentation A 75-year-old male patient presented with progressively worsening pain in the lumbar and gluteal regions, accompanied by impaired mobility. Lumbar spine MRI and PET-CT imaging revealed abnormal signals in the left side of the L5 vertebral body and the left pedicle, indicative of potentially aggressive pathological changes. Pathological biopsy under general anesthesia confirmed a diagnosis of CHE. Given the impossibility of completely resecting the lesion, the patient underwent radiation therapy. After a course of radiotherapy (60Gy/30 fractions), the patient was discharged from the hospital. The patient has been followed up for a period of 20 months with no evidence of recurrence. Conclusion CHE refers to a rare type of tumor that rarely involves the spine. We present a case of CHE occurring in the L5 vertebral body. Given the lack of definitive indications for surgical intervention, radiation therapy was administered, resulting in highly satisfactory therapeutic outcomes and an excellent prognosis.
Keywords: Composite hemangioendothelioma, CHE, Radiation, radiation therapy, Vascular neoplasm
Received: 30 Jun 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Zhang, Luo, Zeng, WANG, Jiang, Ye, Jian, Zhang and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qiaofen Fu, The First Affiliated Hospital of Kunming Medical University, Kunming, China
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