ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
This article is part of the Research TopicAdvances in Diagnosis and Treatment of Endometrial CancerView all 16 articles
Omentectomy for Apparent Early-stage Uterine Serous Carcinoma: a Large Retrospective Cohort Study
Provisionally accepted
- 1Sichuan University West China Second University Hospital, Chengdu, China
- 2West China Second University Hospital, Sichuan University, Chengdu, China
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Objectives: This study aims to compare the effects of different omental assessment methods (omentectomy and omental biopsy) on the long-term prognosis of apparent early-stage uterine serous cancer (USC). Methods: In the retrospective cohort study, a total of 255 women with clinical early-stage USC were included. They were divided into the omentectomy group and the omental biopsy group. The Kaplan-Meier method and the log-rank test were employed to estimate and compare overall survival and disease-free survival between groups. The Cox proportional hazards regression model was used to adjust for potential confounding factors. Results: When compared with undergoing omentectomy, women with apparent early-stage USC who underwent omental biopsy had a deteriorated 5-year OS (HR: 1.76, 95% CI: 1.07-3.52, P=0.009) and 5-year DFS (HR: 1.72, 95% CI: 1.15-2.86, 删除了: A 2 / 12 P=0.012). After adjusting for confounding factors, omental biopsy was independently associated with worsening long-term prognosis in apparent early-stage USC (For DFS, aHR=1.78, 95% CI: 1.13-3.20, P=0.025; For OS, aHR=1.68, 95% CI: 1.11-2.75, P=0.041). Conclusions: For apparent early-stage USC, in terms of long-term survival outcomes, omentectomy is superior to omental biopsy.
Keywords: uterine serous carcinoma, Omentectomy, overall survival, Disease-freesurvival, endometrial cancer
Received: 30 Jun 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Zhang, He, Zheng and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Xu, xuyu_obgy@163.com
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