BRIEF RESEARCH REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1656912
Current quality of life (QOL) questionnaires are not relevant for assessing QOL issues in multiply myeloma patients in the era of modern therapies: Results from a survey with myeloma patients and myeloma healthcare professionals
Provisionally accepted
Catherine Shin Yee Lecat1
Sotirios Bristogiannis2Dipal Mehta1Yadanar Lwin2Joanne Land2Orla Mccourt1,2Emma Dowling2Nuno Correia2Neil K Rabin2
Ke Xu2
Jonathan Sive2Xenofon Papanikolaou2Rakesh Popat2Lydia Lee1
Annabel Mcmillan2Eileen M Boyle1
Kwee Lan Yong1Charalampia Kyriakou2*- 1University College London Cancer Institute, London, United Kingdom
- 2University College London Hospitals NHS Foundation Trust, London, United Kingdom
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As multiple myeloma (MM) patients live longer, maintaining quality of life (QOL) has become an important treatment goal. However, the commonly used general quality of life questionnaires (QOLQs) were developed over 20 years ago. In this survey, 224 MM patients and 48 healthcare professionals (HCPs) were asked to grade the relevance and importance of QOL items from 9 validated, frequently used MM QOLQs. The results from this survey highlighted significant discrepancy between MM patients' and HCPs' perception of important and relevant QOL issues. Whilst MM HCPs found all QOL items relevant, the patients reported a proportion of these items being relevant. These were mainly related to physical functioning, social/family wellbeing, pain and fatigue. This real-world survey stressed the need for the development of an updated QOLQ that is relevant to patients and current MM therapies.
Keywords: Myeloma, Quality of Life, PROM (Patient reported outcome measurement), Healthcare professional (HCP), mutliple myeloma, Health related qualitiy of life
Received: 30 Jun 2025; Accepted: 09 Sep 2025.
Copyright: © 2025 Lecat, Bristogiannis, Mehta, Lwin, Land, Mccourt, Dowling, Correia, Rabin, Xu, Sive, Papanikolaou, Popat, Lee, Mcmillan, Boyle, Yong and Kyriakou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Charalampia Kyriakou, University College London Hospitals NHS Foundation Trust, London, United Kingdom
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