ORIGINAL RESEARCH article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1657405
This article is part of the Research TopicInnovations in Uniportal Lung ResectionView all articles
Conformal Sublobar Electroresection with Volume Optimization Achieves Greater Parenchymal Preservation Than Stapler in Wedge Resection: A Volumetric Analysis
Provisionally accepted
- First Hospital, Peking University, Beijing, China
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Background: Wedge resection is widely applied for small pulmonary nodules, yet stapler-based approaches may result in unnecessary parenchymal sacrifice. The CONSERVO (Conformal Sublobar ElectroResection with Volume Optimization) technique is an electrosurgical, shape-respecting method designed to maximize parenchymal preservation while maintaining oncologic and procedural safety. Method: We retrospectively included 104 patients who underwent stapler-based or CONSERVO wedge resection for solitary pulmonary nodules at our center between 2023 and 2024. Propensity score matching and multivariable linear regression were conducted. Key outcomes included lobe to lung volume ratio loss, operative time, incision length, intraoperative bleeding, drainage volume, and complication rate. Result: Baseline characteristics were well-balanced between groups. The CONSERVO group demonstrated superior parenchymal preservation, with significantly lower lobe-to-lung volume ratio loss (4.66% [IQR 1.68%-7.02%] vs. 11.17% [IQR 8.91%-14.48%], p<0.001) and lobe volume loss (149855.5±221949.3mm3 vs. 220374.6±189597.7mm3, p<0.001). Multivariable regression analysis confirmed the parenchyma saving effect of the CONSERVO technique (Coef. = -0.133, 95% CI: - 0.182 to -0.084, p < 0.001). Additionally, the CONSERVO group was associated with a shorter incision length (23mm [IQR 20-25mm] vs. 35mm [IQR 30-40mm], p<0.001). The operative time was longer in the CONSERVO group (133min [IQR 103-170min] vs. 62min [IQR51-104min], p<0.001). No significant differences were observed in thoracic drainage duration, postoperative drainage volume, or pathological outcomes. Conclusion: The CONSERVO approach achieves meaningful parenchymal preservation and offers additional advantages such as smaller incision size while maintaining oncologic and procedural safety. It may be particularly suited for patients with limited pulmonary reserve or those requiring multiple resections, as well as nodules located close to hilar structures.
Keywords: Small pulmonary nodule, NSCLC, minimally invasive surgery, wedge resection, Diathermy
Received: 05 Aug 2025; Accepted: 10 Oct 2025.
Copyright: © 2025 Zhang, Liu, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: ShiJie Zhang, zhang9999@sohu.com
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