CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1660377
Case Report: Primary Breast Leiomyosarcoma in an 84-Year-Old Male
Provisionally accepted
- Bethune International Peace Hospital, Shijiazhuang, China
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Primary breast leiomyosarcoma is an extremely rare malignancy originating from mesenchymal tissue. Fewer than 10 male cases have been reported globally. This paper reports an 84-year-old male patient. This represents the oldest reported case in the current literature. A painless, slowly enlarging mass was present in his right breast. The mass had a 10-year history. This contrasts sharply with the typically rapidly progressive pattern documented in previous literature. Clinical examination revealed a mobile mass measuring 12 cm × 10 cm in the right breast. No lymphadenopathy was detected. Ultrasound showed a hypoechoic lesion classified as BI-RADS 4a. Magnetic resonance imaging demonstrated plateau-type enhancement. The patient underwent simple mastectomy. Axillary lymph node dissection was not performed. Postoperative pathology and immunohistochemistry confirmed the diagnosis of breast leiomyosarcoma. The patient declined adjuvant radiotherapy. Follow-up at 6 months postoperatively showed no local recurrence or metastasis. This case indicates several points to clinicians. Immunohistochemistry serves as the cornerstone for diagnosing spindle cell tumors of the breast. R0 surgical resection constitutes the core approach for achieving cure. Decisions regarding adjuvant therapy require full consideration of host age and tumor biological behavior. The senescent microenvironment in elderly patients may suppress aggressive tumor progression. Keywords: Breast leiomyosarcoma; Male; Advanced age; Indolent growth; Senescent microenvironment; Case report
Keywords: Breast leiomyosarcoma, male, advanced age, Indolent growth, Senescentmicroenvironment, case report
Received: 05 Jul 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 Yang, Liu, An, Jiao, Li, Qi, Hao, Zhang, Wang and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Guo, luye1977@foxmail.com
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