REVIEW article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1661897
This article is part of the Research TopicFrontiers in Cancer Neuroscience: Unraveling the Complex Interplay of Neural Mechanisms in Tumorigenesis and TherapeuticsView all articles
Glioma-Neuron Interactions: Insights from Neural Plasticity
Provisionally accepted
- Peking University Third Hospital, China, China
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The development of gliomas is linked to neuroplasticity. Neurons, which are largely nonregenerative in adulthood, rely on axons and synapses to rebuild the neural network in response to experience and injury. Neural stem cells and immune cells coordinate "creation" (e.g., neurogenesis) and "clearance" (e.g., synaptic pruning), guided by signals from neural circuits. This review summarizes neuroplasticity mechanisms and explores their connection to gliomas, revealing that glioma cells hijack neural network derived signals to promote growth, migration, and stem-like properties, while simultaneously disrupting normal neural conduction. Similar to oligodendrocyte precursor cells (OPCs), gliomas exploit neural network regulation but are prone to uncontrolled proliferation. Moreover, glioma induced neural hyperexcitability disrupts circuit homeostasis, creating a permissive microenvironment for glioma progression. Consequently, neuroplasticity will contribute to the study of glioma related mechanisms and the development of more targeted strategies for prevention and control.
Keywords: Glioma, neural mechanisms, neuroplasticity, neural networks, Migration, glioma stem cell, tumorigenesis, Tumor Microenvironment
Received: 08 Jul 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 FENG and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Yang, Peking University Third Hospital, China, China
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