ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1662079
This article is part of the Research TopicAdvancements in Personalized Medicine for Head and Neck Cancer: Molecular-based Approaches to Treatment and CareView all 12 articles
Multifactorial Analysis and Construction of a Nomogram Model for Postoperative Recurrence of Glomus Jugulare Tumor
Provisionally accepted
- Department of Otolaryngology Head and Neck Surgery, PLA General Hospital, Beijing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: To derive and validate a prognostic nomogram for predicting postoperative recurrence in patients with glomus jugulare tumor(GJT) to assist clinical decision-making. Methods: A retrospective analysis was conducted on the clinical data of a total of 318 patients diagnosed with GJT at a single tertiary medical center. The study collected information on patient demographics, clinical symptoms and signs, examination results, and the extent of tumor growth. Patients were categorized into two groups based on DFS (Disease - free survival): those who experienced recurrence and those who did not. A nomogram model was developed using logistic regression to analyze the risk of postoperative recurrence. Results: Multivariate logistic regression analysis identified age, immunohistochemical expression levels of Ki-67 and S-100 and tumor invasion extent were significantly associated as independent predictors. These independent predictors were incorporated into a nomogram. The logistic regression-based nomogram showed excellent predictive accuracy of the nomogram model in the training set, validation set, and test set, with corresponding areas under the curve (AUC) of 0.863, 0.711, and 0.784, respectively. Conclusions: The nomogram effectively predicts GJT recurrence, validated internally and externally, aiding clinical risk stratification.
Keywords: GJT, nomogram, Postoperative recurrence, prognostic factors, AUC
Received: 08 Jul 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Li, Lu, Guo, Kou, Chen, Yang and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weidong Shen, Department of Otolaryngology Head and Neck Surgery, PLA General Hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.