CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1662686
This article is part of the Research TopicCase Reports in Radiation Oncology: 2025View all 20 articles
Diverse Radiotherapy Fractionation in Malignant Melanoma: A Case Report
Provisionally accepted
- The Affiliated Cancer Hospital of Nanjing Medical University, Nan jing, China
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Malignant melanoma (MM) is a highly aggressive tumor, with a median overall survival (mOS) of only 8 to 12 months for its metastatic form. However, studies focusing on the efficacy of different radiotherapy (RT) fractionation regimens for MM are limited. Here, we report the case of a 60-year-old male who presented with a one-month history of intermittent abdominal pain and was subsequently diagnosed with MM. Following disease progression on systemic therapy, the patient was treated with different fractionation regimens, including 5 Gy per fraction and 3 Gy per fraction. After the failure of immunotherapy, RT effectively controlled the tumor burden. Notably, the patient received different doses of RT and achieved different outcomes. This case report demonstrates that RT could serve as a viable option for patients who have developed resistance to immunotherapy and low-dose RT may enhance tumor immune response when combined with immunotherapy.
Keywords: malignant melanoma, Radiotherapy, Melanoma of unknown primary, Immunotherapy, targeted therapy, case report
Received: 18 Jul 2025; Accepted: 10 Sep 2025.
Copyright: © 2025 Shen, Ge, Zhang, Gao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lijun Wang, dr_wanglj@njmu.edu.cn
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