CASE REPORT article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1663079
This article is part of the Research TopicCommunity Series in Unveiling the Next Generation of Cancer Immunity & Immunotherapy in Lung Cancer: Volume IIView all 4 articles
Long-term Survival Following Multimodal Therapy for Lung Cancer with Hepatic Metastasis: A Case Report
Provisionally accepted
- 1Shaoxing People's Hospital, Shaoxing, China
- 2Shaoxing University, Shaoxing, China
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Background:The liver serves as a predominant metastatic site in advanced lung cancer, with patients developing hepatic metastases demonstrating particularly dismal prognosis and a median survival of approximately 5 months. Currently, no consensus has been established regarding optimal therapeutic strategies for lung cancer with liver metastases. Case presentation:A patient with advanced lung cancer and oligometastatic liver metastases achieved significant tumor regression in both pulmonary and hepatic lesions following combined immunotherapy and chemotherapy. Subsequent radiofrequency ablation was performed for the liver metastasis, while surgical resection of the primary lung lesion resulted in pathological complete response (pCR). The patient has maintained long-term survival without evidence of disease recurrence. Conclusions: For patients with advanced lung cancer and oligometastatic liver metastases demonstrating favorable response to combined immunotherapy and chemotherapy, consolidative surgical resection with adjunctive liver-directed local therapy may be considered, potentially conferring long-term survival benefits.
Keywords: Non-small cell lung cancer(NSCLC), Hepatic metastasis, Surgery, Radiofrequency ablation(RFA), case report
Received: 10 Jul 2025; Accepted: 23 Sep 2025.
Copyright: © 2025 Junjun, Zhang, Lingjun, Guangmao and chu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yu Guangmao, yugm@usx.edu.cn
Zhang chu, zhangchu@usx.edu.cn
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