REVIEW article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1664340
This article is part of the Research TopicCutting-Edge Strategies in Screening, Prevention, and Treatment in Gynaecologic OncologyView all 21 articles
Gold Nanoparticles in the Diagnosis and Treatment of Ovarian and Cervical Cancers: A Comprehensive Understanding
Provisionally accepted
- 1Nanjing Women and Children’s HealthCare Hospital, Nanjing, China
- 2Jiangsu Cancer Hospital, Nanjing, China
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Abstract: Cervical and ovarian cancers pose a significant global threat to women's health. Despite substantial medical advances in recent decades, gynecological malignancies remain a leading cause of female mortality, constrained by factors such as multidrug resistance, treatment toxicity, asymptomatic presentation in early stages, and genetic heterogeneity. Gold nanoparticles (AuNPs), leveraging their exceptional biocompatibility and multifunctional capabilities, demonstrate considerable potential across diverse fields including bioimaging, liquid biopsy, photothermal therapy, and targeted chemotherapy, thereby advancing precision oncology. Accordingly, this review synthesizes and analyzes the emerging applications of AuNPs in gynecological tumors over the past five years. Moving beyond superficial descriptions of functional features often limited in previous reviews, it places greater emphasis on elucidating the intrinsic relationships and mechanisms between functions from the perspective of their physicochemical properties. It further highlights the critical importance of AuNPs for constructing integrated diagnostic and therapeutic platforms. Simultaneously, this review provides a balanced examination of the challenges hindering the clinical translation of AuNPs and offers insights and perspectives on addressing these issues. It is anticipated that AuNPs may evolve into highly effective diagnostic and therapeutic strategies in the future.
Keywords: Gynecological malignant tumors, cervical cancer, ovarian cancer, Nanotechnology, gold nanoparticles, diagnosis, Treatment
Received: 11 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Zhang, Li, Jiang, Shi, Hou, Fu and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyan Shi, Nanjing Women and Children’s HealthCare Hospital, Nanjing, China
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