REVIEW article
Front. Oncol.
Sec. Cancer Genetics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1665024
The role of extrachromosomal DNA in tumorigenesis and progression
Provisionally accepted
- The Fourth People's Hospital of Zigong City, Zigong, China
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In tumors, extrachromosomal DNA (ecDNA) is an important driver of oncogene expression, genomic instability, the evolution of drug resistance, and poor patient prognosis. ecDNA is present in various tumors but is rarely found in normal cells. Here, we provide a detailed review of the structure, genetics, occurrence, outcomes, and functions of ecDNA, offering further reference for research on ecDNA.
Keywords: ecDNA, tumorigenesis, oncogene, heterogeneity, Cancer Progression
Received: 14 Jul 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Ma, Yu, Wu and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: YangMa Ma, The Fourth People's Hospital of Zigong City, Zigong, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.