CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1665645
This article is part of the Research TopicCase Reports in Radiation Oncology: 2025View all 19 articles
The role of Radiotherapy for patients with primary tracheal carcinoma: two case reports of Tracheal carina Squamous cell carcinoma and literature review
Provisionally accepted
- 1Second Hospital of Hebei Medical University, Shijiazhuang, China
- 2The Second Hospital of Hebei Medical University, Shijiazhuang, China
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Primary tracheal carcinoma is a rare malignant tumor, its optimal treatment strategy is not formally proven. Surgery, especially complete surgical excision is often considered as the first-line treatment. Chemotherapy is reported ineffective. There is a growing body of evidence to prove radiotherapy could achieve better local control and produce survival benefit for incomplete excision, the surgical margin with questionable, or unresectable lesions, but the effect, total dose and fraction dose of radiotherapy remain controversial. We report two cases of primary tracheal squamous cell carcinoma at tracheal carina: a 74 year old male presented a carina unresectable tracheal carcinoma, and a 55 years old female with a tracheal tumor, both of them treated with radical radiotherapy demonstrated satisfactory local control. And review the current progress of radiotherapy in primary tracheal carcinoma.
Keywords: Primary tracheal carcinoma, Radiotherapy, Radiotherapy dose, chemotherapy, Surgery
Received: 14 Jul 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Chang, Tian, Zhao, Ge, Li, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huizhi Liu, The Second Hospital of Hebei Medical University, Shijiazhuang, China
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