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CASE REPORT article

Front. Oncol.

Sec. Pediatric Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1665968

This article is part of the Research TopicCase Reports in Pediatric Oncology: 2025View all 6 articles

Prolonged Overall Survival in a Child with Multimetastatic Retinoblastoma Treated with Anti-GD2 Monoclonal Antibody Dinutuximab Beta: A Case Report

Provisionally accepted
  • Ospedale Pediatrico Bambino Gesu IRCCS, Rome, Italy

The final, formatted version of the article will be published soon.

High-dose chemotherapy with autologous stem cell rescue has improved outcomes in patients with metastatic retinoblastoma (RB). However, significant short-and long-term toxicities—especially in very young children with a constitutional RB1 gene mutation—highlight the need for alternative therapeutic strategies. Monoclonal antibodies targeting tumor-associated antigens such as GD2 have emerged as promising agents in this setting. We report the case of a 2-year-old child diagnosed with extensive left-eye retinoblastoma and massive extraocular dissemination at presentation. The patient was treated with systemic conventional and high-dose chemotherapy combined with intrathecal Topotecan. As consolidation therapy, the child received three courses of the anti-GD2 monoclonal antibody Dinutuximab beta over a 10-day schedule. The patient achieved complete remission and remains disease-free six years after the initial diagnosis. This case suggests that anti-GD2 immunotherapy, used as consolidation treatment, may improve the prognosis of patients with advanced retinoblastoma and potentially reduce the toxicity associated with standard therapies. Further clinical investigation is warranted to validate these findings.

Keywords: Retinolastoma, Extraocular, High-dose chemotherapy, anti-GD2 monoclonal antibodies, intrathecal topotecan

Received: 14 Jul 2025; Accepted: 30 Sep 2025.

Copyright: © 2025 Russo, Di Ruscio, Carboni, Del Baldo, De Pasquale, Valente, Di Giannatale, Serra, De Vito, Mastronuzzi, Quintarelli, DE ANGELIS and Milano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ida Russo, ida.russo@opbg.net

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