REVIEW article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1666126
This article is part of the Research TopicRedefining Care: Integrating Surgical Innovations and Precision Medicine in Breast Cancer TreatmentView all articles
Research progress of molecular typing and targeted therapy for triple-negative breast cancer
Provisionally accepted
Dalin Xiang
Xin Yue*- The First Affiliated Hospital of Yangtze University, Jingzhou, China
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Triple-negative breast cancer (TNBC) is difficult to treat due to its high heterogeneity, strong invasiveness, high risk of recurrence and metastasis, and poor prognosis. Chemotherapy is still its main treatment, but limited by the lack of specific targets, drug resistance and other factors, the conventional efficacy is poor. In recent years, advances in genomics and other technologies have promoted the deepening of molecular typing studies and the development of targeted therapy for TNBC, providing a new direction for breaking through the therapeutic dilemma. Based on the biological characteristics of TNBC and the current treatment status, this article systematically reviews the latest progress of its molecular typing system, and discusses the breakthrough research results of targeted therapy strategies, aiming to provide a theoretical basis and practical reference for the precise treatment of TNBC.
Keywords: Triple-negative breast cancer, High heterogeneity, strong invasiveness, Molecular Typing, targeted therapy
Received: 15 Jul 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Xiang and Yue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Yue, The First Affiliated Hospital of Yangtze University, Jingzhou, China
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