ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1667226
Prognostic Parity in Second Primary Oral Squamous Cell Carcinoma Following Hematologic Malignancy: A Retrospective Cohort Analysis
Provisionally accepted
- 1Department of Oral and Maxillofacial Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China
- 2The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
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Backgrounds: Prognosis and optimal management strategies of second primary oral squamous cell carcinoma (OSCC) following a history of hematologic malignancies (HM) remain uncertain. We investigated whether HM history affects OSCC outcomes or necessitates treatment modifications. Patients and Methods: This retrospective cohort study included 2486 OSCC patients: 14 with OSCC as a second primary malignancy post-HM (SPM group) and 2472 with primary OSCC (non-SPM group). Using propensity score matching (PSM), we created two cohorts: 1:17 (13 SPM vs 232 non-SPM) and 1:3 (13 SPM vs 38 non-SPM). Outcomes were disease-free survival (DFS), overall survival (OS), and disease-specific survival (DSS). Survival differences were analyzed using log-rank tests. Multivariate Cox regression identified prognostic predictors. Results: No significant survival differences existed between SPM and non-SPM groups in either cohort (1:17: DFS 53.8% vs 68.9%, p=0.102; OS 69.2% vs 81.3%, p=0.170; DSS 69.2% vs 82.2%, p=0.147. 1:3: DFS 53.8% vs 63.2%, p=0.302; OS 69.2% vs 76.3%, p=0.532; DSS 69.2% vs 78.9%, p=0.430). Cox regression identified independent predictors: DFS: Age (p=0.001), T stage (p<0.001), N stage (p<0.001); OS and DSS: Age (p<0.001), T stage (p<0.001), N stage (p<0.001), pathological grade (p<0.001), prior HM was not an independent predictor. Conclusions: A history of HM does not independently predict the prognosis of second primary OSCC nor necessitate modifications to standard OSCC treatment.
Keywords: oral squamous cell carcinoma, Hematologic malignancy, SecondPrimary Malignancy, prognosis, surgical treatment
Received: 16 Jul 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Yu, Li, Huang, Zhang, Zhou, Feng and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhengxue Han, Department of Oral and Maxillofacial Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China
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