REVIEW article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1669228
Influence Factor and Mechanism of FLASH Effect
Provisionally accepted
- 1Sichuan University, Chengdu, China
- 2West China Hospital of Sichuan University, Chengdu, China
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FLASH radiotherapy (FLASH-RT) represents an innovative treatment modality utilizing ultra-high dose-rate irradiation (>40 Gy/s). The FLASH effect, induced by FLASH-RT, is characterized by the selective radioprotective effect of normal tissue while preserving tumor control efficacy. Currently, FLASH effect has been confirmed in many preclinical studies and clinical studies. However, the mechanism and the influencing factors of FLASH effect remain ambiguous. This review systematically summarizes current understanding of the mechanism and influencing factors of FLASH effect, providing theoretical basis for the future study and application of FLASH-RT.
Keywords: ultra-high dose-rate1, FLASH radiotherapy2, Mechanism3, Influencing factor4, FLASH effect5
Received: 19 Jul 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Feng, He, Ye and Xiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lisha Xiang, Sichuan University, Chengdu, China
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