ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1671027
This article is part of the Research TopicLiver Cancer Awareness Month 2024: Current Progress and Future Prospects on Advances in Primary Liver Cancer Investigation and TreatmentView all 23 articles
Comparative Analysis of External Beam Radiotherapy versus Portal Vein Stent Implantation Combined with Local and Systemic Therapy in Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus: A Real-World Retrospective Study
Provisionally accepted
- 1Department of Oncology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China, Liuzhou, China
- 2Affiliated Zhongshan Hospital of Dalian University, Dalian, China
- 3Beijing You'an Hospital Affiliated to Capital Medical University, Beijing, China
- 4Qingyuan People's Hospital, Qingyuan, China
- 5Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China, Nanning, China
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Objective: To compare the effectiveness and safety of External Beam Radiotherapy (EBRT) versus Portal Vein Stent Implantation (PVSI) when combined with local interventional therapy and TKI plus ICIs in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT), providing real-world evidence for clinical decision-making. Methods: This retrospective study compared the effectiveness of EBRT versus PVSI when combined with local intervention and TKI plus ICIs. We assessed objective response rate (ORR), disease control rate (DCR), overall survival (OS), progression-free survival (PFS), and safety outcomes, including complications and liver injury. Univariate and subgroup analyses identified prognostic factors to support personalized treatment decisions. Results: The study enrolled 67 patients (EBRT group, n = 26; PVSI group, n = 41) with comparable baseline characteristics (P > 0.05). During a
Keywords: external beam radiotherapy, Portal vein 125I seed stent implantation, Hepatocellular Carcinoma, Portal vein tumor thrombus, Local and systemic therapy
Received: 22 Jul 2025; Accepted: 12 Sep 2025.
Copyright: © 2025 Wenping, Wang, Chen, Wang, Li, Yuan, Mao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenqi Liu, Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China, Nanning, China
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