CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1672264
Undifferentiated high-grade sarcoma with UES-like features in the retroperitoneum: a case report with TP53 p.R306 mutation
Provisionally accepted
- 1China Medical University, Shenyang, China
- 2The First Hospital of China Medical University, Shenyang, China
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Undifferentiated embryonal sarcoma(UES) is a rare, highly malignant tumor mainly originating from the liver, composed of primitive undifferentiated mesenchymal cells.Undifferentiated embryonal sarcoma of the liver(UESL) is a rare entity. Here, we report a case of abdominal mass in a young female that morphologically resembles UES without liver involved. Notably, the mass was located from the abdominal cavity to the retroperitoneum without any correlation with the liver. The patient had no history of prior tumors, and detailed examinations of the liver revealed no definite lesions. In addition, we propose undifferentiated high-grade sarcoma with UES-like features in the retroperitoneum, in which TP53 gene mutation may serve as the initiating factor for tumorigenesis.
Keywords: high-grade sarcoma, polymorphic undifferentiated sarcoma, liver undifferentiatedembryonal sarcoma, UESL, Pathology
Received: 24 Jul 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Zhu, Sun, Wang and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xuyong Lin, cmupatho@163.com
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