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ORIGINAL RESEARCH article

Front. Oncol.

Sec. Cancer Imaging and Image-directed Interventions

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1672274

Research on Breast Tumor Segmentation Based on the Mamba Architecture

Provisionally accepted
  • Anhui University of Chinese Medicine, Hefei, China

The final, formatted version of the article will be published soon.

Medical image segmentation is fundamental for disease diagnosis, particularly in the context of breast cancer, a prevalent malignancy affecting women. The accuracy of lesion localization and preservation of image details are essential for ensuring the integrity of lesion segmentation. However, the low resolution of breast tumor B-mode ultrasound images poses challenges in precisely identifying lesion sites. To address this issue, this study introduces the Mamba architecture model, which combines three foundational models with the long-sequence processing model Mamba to develop a novel segmentation model for breast tumor ultrasound images. The selective mechanism and hardware-aware algorithm of the Mamba model enable longer sequence inputs and faster computing speeds. Moreover, integrating a complete chain of VMamba blocks into the basic model enhances segmentation accuracy and image detail processing capabilities. Experimental segmentation was performed on two benchmark ultrasound datasets (BUSI and BUS-BRA) using both the baseline and improved models. The results were compared using metrics such as Dice and IoU, with additional evaluations conducted under small-sample training conditions. This study is intended to provide guidance for the future development of medical image segmentation. Moreover, the experimental results demonstrate that the model incorporating the Mamba architecture achieves superior performance on breast ultrasound images.

Keywords: Breast tumors, Medical image segmentation, Mamba, Selective mechanism, Hardware-aware algorithm

Received: 25 Jul 2025; Accepted: 23 Oct 2025.

Copyright: © 2025 Wei, Wu and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Guangming Shao, guangmingshao@163.com

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