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CASE REPORT article

Front. Oncol.

Sec. Hematologic Malignancies

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1672690

Uncommon co-occurrence of different renal histopathological entities in a patient with multiple myeloma and lymphoplasmacytic lymphoma: a case report

Provisionally accepted
Marco TalaricoMarco Talarico1,2Gisella VischiniGisella Vischini3Simona BarbatoSimona Barbato2,4Roberta RestucciaRoberta Restuccia2,4Simone MasciSimone Masci2,4Ilaria SacchettiIlaria Sacchetti2,4Enrica ManzatoEnrica Manzato2,4Stefano GhibelliniStefano Ghibellini2,4Michele PuppiMichele Puppi2,4Miriam IezzaMiriam Iezza2,4Ilaria RizzelloIlaria Rizzello2,4Lucia PantaniLucia Pantani4Paola TacchettiPaola Tacchetti4Enrica BorsiEnrica Borsi2,4Vincenza SolliVincenza Solli2,4Carolina TerragnaCarolina Terragna4Claudio AgostinelliClaudio Agostinelli2,5Gaetano La MannaGaetano La Manna2,3Michele CAVOMichele CAVO2Elena ZamagniElena Zamagni1,2*Katia MancusoKatia Mancuso2,4
  • 1IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico di Sant'Orsola, Bologna, Italy
  • 2Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy, BOLOGNA, Italy
  • 3Nephrology, Dialysis and Renal Transplant Unit, IRRCS Azienda Ospedaliero-Universitaria, Bologna, Italy, BOLOGNA, Italy
  • 4IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Bologna, Italy, BOLOGNA, Italy
  • 5Hematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy, BOLOGNA, Italy

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In patients with plasma cell dyscrasias presenting with kidney injury, renal biopsy usually displays the presence of a single histologic damage, but the coexistence of heterogeneous damages has been occasionally described and associated with worse renal outcome. In this report, we describe the case of a patient with concomitant diagnosis of multiple myeloma and lymphoplasmacytic lymphoma, presenting with acute kidney injury and renal biopsy revealing the unexpected concurrent presence of several different renal damages, achieving a good hematologic response and dialysis-independence after anti-myeloma therapy.

Keywords: Multiple Myeloma, Lymphoplasmacytic lymphoma, Acute Kidney Injury, renal damage, renal biopsy

Received: 24 Jul 2025; Accepted: 17 Sep 2025.

Copyright: © 2025 Talarico, Vischini, Barbato, Restuccia, Masci, Sacchetti, Manzato, Ghibellini, Puppi, Iezza, Rizzello, Pantani, Tacchetti, Borsi, Solli, Terragna, Agostinelli, La Manna, CAVO, Zamagni and Mancuso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Elena Zamagni, e.zamagni@unibo.it

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