CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
This article is part of the Research TopicPrecision Oncology: Integrating Molecular Mechanisms, Organoid Models, and Omics Technologies for Personalized Cancer CareView all 5 articles
Case Report: Stable Disease Achieved in a Patient with Metastatic Castration-Resistant Prostate Cancer Following Personalized Treatment
Provisionally accepted
- 1Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China
- 2Shanxi Provincial Cancer Hospital, Taiyuan, China
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Castration-resistant prostate cancer (CRPC), particularly metastatic castration-resistant prostate cancer (mCRPC), is a leading cause of cancer-related death in men worldwide. Despite great achievements in the treatment of mCRPC, the clinical treatment still faces enormous challenges due to natural or acquired drug resistance. Tumor organoids, an in-vitro three-dimensional microstructure, have been demonstrated to predict the response to various therapies to optimize patient outcomes at the individual level. Here, we shared a mCRPC patient who achieved stable disease after treatment with the drugs sensitive in organoid drug screening, despite failure in previous several standard therapies. This typical case highlights that prostate cancer organoids may serve as a potential companion tool to optimize treatment options and improve treatment outcomes, thus realizing the personalized management of mCRPC patients, especially those exhausting the standard therapies.
Keywords: castration-resistant prostate cancer, tumor organoids, Bicalutamide, personalizedmanagement, drug screening
Received: 25 Jul 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Zhang, Zhang, Pang and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuqing Wei, weishuqing1972@163.com
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