CASE REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
Transformation of T-Lymphoblastic Lymphoma into Acute Myeloid Leukemia After Recurrence A Case Report and Literature Review
Provisionally accepted
- 1The First Affiliated Hospital of Henan University of Science and Technology, 请选择, China
- 2The First Affiliated Hospital , College of Clinical Medicine, Henan University of Science and Technology,Luoyang,471000, Henan, China
- 3Clinical Medical College of Henan University of Science and Technology, Henan Province, China
- 4The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China
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Objective: To investigate the diagnosis and treatment of the condition of T-lymphoblastic lymphoma (T-LBL) transforming into acute myeloid leukemia (AML) following recurrence.Methods: We conducted a retrospective analysis of a patient admitted to the First Affiliated Hospital of Henan University of Science and Technology in July 2022 with recurrent T-LBL that progressed to AML. Clinical manifestations, genetic and histopathological findings, and treatment outcomes were evaluated, complemented by a literature review.Results: The patient, initially diagnosed with T-LBL, achieved complete remission (CR) after combination chemotherapy. Following treatment cessation, the disease recurred and transformed into AML.Conclusion: The transformation of T-LBL into AML is exceedingly rare, and the underlying mechanisms of lineage switch remain unclear. Venetoclax combined with chemotherapy and allogeneic hematopoietic stem cell transplantation (allo-HSCT) may improve prognosis in such cases.
Keywords: T-lymphoblastic lymphoma, Acute Myeloid Leukemia, Lineage transformation, therapy-related leukemia, venetoclax
Received: 25 Jul 2025; Accepted: 27 Nov 2025.
Copyright: © 2025 Yang, Zhao and Mei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoqiang Zhao
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