The Effect of Traditional Chinese Medicine on Patients Undergoing Targeted Therapy for Liver Cancer: A Systematic Review and Meta-Analysis

Hongting Yan¹Yingjie Li²Bin Guo^3*Bing Yang^1*Dongxin Tang^1*

• ¹Guizhou University of Traditional Chinese Medicine, Guiyang, China
• ²Integrated Hospital of Traditional Chinese Medicine of Southern Medical University, Guangzhou, China
• ³Other

Objective: Evaluate the therapeutic efficacy and safety of Traditional Chinese Medicine(TCM)in patients with primary liver cancer (PLC) receiving targeted therapy. Methods: We conducted a comprehensive search of databases. The search scope covered the period from the establishment of the databases to April 2025. We included 49 randomized controlled trials (RCTs) evaluating targeted therapy for primary liver cancer with TCM. Efficacy and safety outcomes were assessed using risk ratios (RR), standardized mean differences (SMD), and their 95% confidence intervals (CI). Results: Targeted therapy for liver cancer patients who received TCM treatment showed improvements in objective response rate (ORR) (RR, 1.49 [1.33-1.66], P < 0.0001), disease control rate (DCR) (RR, 1.32 [1.25,1.40], P < 0.0001), the 1-year survival (RR, 1.50 [1.20,1.88]; P = 0.0004) and Karnofsky Performance Status (KPS) (SMD, 1.34 [0.86,1.81]; P < 0.0001), and can reduce the incidence of adverse events, as well as to some extent decrease the production of tumor markers and related inflammatory factors. Conclusion: TCM enhances the efficacy and safety of targeted therapy in PLC, offering superior clinical outcomes with fewer adverse effects. These findings support its potential integration into standard treatment protocols.