ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cardio-Oncology
This article is part of the Research TopicCardiomyopathy and Heart Failure in OncologyView all 12 articles
Atrial Arrhythmias Related to Antitumor Treatment in Patients with Coronary Heart Disease and Malignant Tumors
Provisionally accepted
- 1Zhejiang Hospital, Hangzhou, China
- 2Shaoxing University Affiliated Hospital, Shaoxing, China
- 3Other
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Aims: This study investigated the occurrence of arrhythmias in patients with malignant tumors and coronary heart disease (CHD) during antitumor drug treatment. Methods: 109 patients with malignant tumors undergoing antitumor treatment at Zhejiang Hospital from January 2023 to January 2024 were analyzed. All patients underwent 12-lead ECG before and after each chemotherapy cycle. The primary endpoint was the occurrence of new arrhythmias recorded through ECG. Univariate and multivariate logistic regression analysis were performed to recognize the risk factors. Results: Atrial arrhythmias occurred in 13 cases (11.93%). The incidence of atrial arrhythmias was significantly higher in the CHD group compared to the non-CHD group (27.27% vs 1.54%; P < 0.001). Multivariate logistic regression analysis indicated that smoking (P = 0.009), ischemic heart disease (P = 0.006), and left ventricular ejection fraction < 50% (P = 0.014) increased the risk of developing arrhythmias after antitumor treatment. Conclusion: Atrial arrhythmias are more common in cancer patients with CHD when undergoing antitumor treatment. A history of smoking, ischemic heart disease, and reduced left ventricular ejection fraction increases the risk of atrial arrhythmias after antitumor therapy.
Keywords: atrial arrhythmias, coronary heart disease, Antitumor treatment, Risk factors, Cancer
Received: 30 Jul 2025; Accepted: 30 Oct 2025.
Copyright: © 2025 Zhang, Zhang, Ren and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chenkai Xu, xck19860501@163.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.