CASE REPORT article
Front. Oncol.
Sec. Head and Neck Cancer
Case Report: One Case of Mixed Medullary-Papillary Thyroid Carcinoma with Concurrent Medullary and Papillary Carcinoma and Mixed Lymph Node Metastasis
Provisionally accepted
De-Shi Yang1
Jing He2*- 1The Third Hospital of Mianyang,Sichuan Mental Health Center, Mianyang Third People's Hospital, Mianyang, China
- 2Mianyang Third People's Hospital, Mianyang, China
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Introduction: By reviewing the diagnosis and treatment process of a rare case of mixed medullary-papillary thyroid carcinoma (MMPTC) in the right lobe, medullary thyroid carcinoma (MTC) combined with papillary thyroid carcinoma (PTC) in the left lobe, and multiple MTCs in the isthmus with mixed lymph node metastasis, we systematically analyzed its pathological features and immunophenotype. Case presentation: A 65-year-old Han male patient was found to have a hypoechoic nodule(TI-RADS category 5) in the right lobe of the thyroid gland during a physical examination. Additionally, enlarged lymph nodes were found in the right neck, accompanied by structural abnormalities(The morphology is regular, with a distinct boundary. The internal echo is heterogeneous, presenting anechoic areas and punctate hyperechoic foci. The lymph hilar structure is poorly visualized. Color Doppler Flow Imaging (CDFI) reveals punctate blood flow signals within and surrounding the lesion.).Serum calcitonin (CT), carcinoembryonic antigen (CEA), and thyroglobulin (TG) were all elevated. Subsequently, fine-needle aspiration cytology (FNAC) was performed on the right lobe thyroid mass and a biopsy was taken from the right cervical lymph nodes. The FNAC results indicated that the right lobe thyroid mass was suggestive of MTC. Meanwhile, metastatic PTC was found in the right cervical lymph node biopsy tissue.The patient subsequently underwent a total thyroidectomy combined with radical lymph node dissection in the thyroid and maxillofacial surgery department. The postoperative radical specimen showed that cancer foci were visible in the left lobe, isthmus and right lobe of the thyroid. Among them, a focus of MMPTC was found in the right lobe of the thyroid gland, with the tumor mainly composed of MTC components; in the left lobe, a coexisting lesion of PTC and MTC was found, the two foci are separated by normal thyroid tissue. Two foci of MTC were found in the isthmus of the thyroid gland. A total of 88 lymph nodes were dissected, among which 21 were found to have cancer metastasis. Postoperative serum CEA dropped to the normal level, and CT showed a significant decrease compared with that before the operation.
Keywords: Mixed medullary papillary thyroid cancer, medullary thyroid carcinoma, Papillary thyroid carcinoma, Pathological diagnosis, case report
Received: 30 Jul 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Yang and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing He, drjinghe@hotmail.com
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